Holders Wigan will be at home to their arch-rivals St Helens in the quarter-finals of the Challenge Cup.
The only Championship side, Leigh Centurions, host the Super League champions Leeds Rhinos, who have lost in the final for the past two years. In the remaining ties, Huddersfield Giants take on London Broncos and Catalan Dragons face Warrington Wolves.
The Wigan coach, Shaun Wane, said: "I'm pleased with that. It's great for the town. If we are going to get to the final we're going to come up against great teams."
Wigan secured a 28-10 win over Saints in the Good Friday derby but Wane is expecting a sterner test in the cup. "This is a fresh start," he said. "Jonny Lomax didn't play much against us that day. I'm looking forward to a real tough game."
The game at Leigh is a repeat of the 1971 final when Alex Murphy captained and coached the club to a shock win over Leeds. Leigh's coach, Paul Rowley, said: "They're the world champions so you couldn't ask for a bigger or more attractive game. I've got the utmost respect for Leeds and their coach [Brian McDermott]. I like watching Leeds and it will be a privilege to host them. It's up to our club and the town to get behind the players and fill the stadium."
The matches will be played on the weekend of 11 to 13 May.