"I'm very disappointed," Mulholland said. "I don't know what I'm going to do now, but, if I'm going to be sacked, this is a great place to be sacked," he said.
Two other coaches who have recently lost their jobs - John Monie at Auckland and Andy Goodway at Oldham - have been mentioned as possible successors. In the short term, the club captain, David O'Donnell, will take charge of training and will select the side to play Castleford on Sunday.
Half the 12 Super League coaches have now been replaced, within three months of the start of the season.
The former Wigan and Great Britain player, Phil Clarke - back in England for tests on the neck injury that ended his playing career with Sydney City Roosters last year - has denied trying to oust Wigan's chairman, Jack Robinson. "But if there was a changing of the guard and there was any way I could help Wigan, then I would feel honoured to do so," he said.