This was a harsh lesson for Hull who, despite tremendous effort, did not have the class to trouble a competent Wigan side.
Tries by Neil Cowie and Simon Haughton gave Wigan a 12-0 lead after 17 minutes. It was an uphill battle for Hull from that point.
Meanwhile Huddersfield's inspirational captain Danny Russell fired them to a 28-6 win over out-of-sorts Warrington, their first Super League victory of the season, at the eighth attempt.
Garry Schofield's men recovered after falling behind to Jon Roper's early touchdown.
Huddersfield replied through Neil Harmon and Craig Weston and continued where they had left off after the break.
Substitute Paul Cook scored the fifth Giants try in the closing seconds to seal the points.Reuse content