World champions South Africa will play the Leicester Tigers at Welford Road in November after the friendly fixture received approval from the RFU.
Leicester have invited the Springboks to celebrate the opening of their new Caterpillar Stand, and the match will open South Africa's autumn tour, which features Tests against France, Italy and Ireland.
Tigers chairman Peter Tom said: "We have had some wonderful games against touring teams here at Welford Road in the past but we have never played the world champions.
"To play against the world champions South Africa is a real honour and will be a fitting way to celebrate the opening of the new Caterpillar Stand.
"The game has got Tigers supporters buzzing and our ticket office has been receiving enquiries from rugby fans from all over the world."