Andrew Sheridan is set to miss England's Grand Slam bid after suffering a torn calf.
The Sale loosehead prop was forced off in the first half of England's 17-9 victory over France on Saturday.
England manager Martin Johnson said Sheridan faced between two and four weeks out, so he would "probably" miss the games against Scotland and Ireland.
Sheridan, who will definitely miss the Scotland game, has suffered a grade two tear of the calf and has returned to Sale today from England's training camp in Oxford.
Fly-half Toby Flood has undergone a scan on his injured Achilles and England remain confident he will be fit to face Scotland.
Johnson said: "Sheridan has a grade two tear, so it is not good. I think he is probably out of the championship. I am hearing it is two to four weeks.
"He is probably out of the championship unless there is some huge improvement very quickly.
"Flood is okay. He has a bit of Achilles tendon soreness. We think he will be fine (to play Scotland) but we will be very cautious with him this week."
With Flood unlikely to train until Thursday at the earliest, England are set to keep Jonny Wilkinson in camp and not release him back to Toulon this weekend.
A final decision on that will be taken later today.Reuse content