Fallen champions Wales will go into their RBS Six Nations finale against Scotland next weekend without points machine Leigh Halfpenny.
Warren Gatland's squad will begin the recovery process on Monday from a sobering 29-18 Twickenham defeat against title contenders England.
But they will host the Scots without full-back Halfpenny, who scored all of Wales' points in a goalkicking masterclass and then dislocated his shoulder helping to thwart an England try.
"Leigh has dislocated his shoulder, so I think that's him gone for the rest of the season," Gatland said.
"That will be Leigh's season over, which is disappointing for him."
England 29 Wales 18: Player ratings from Twickenham
England 29 Wales 18: Player ratings from Twickenham
1/30 Mike Brown 8/10
He may be Mr Angry, but Mr Reliable is not far off the mark. Dangerous with ball in hand and proved once again what a player he is. Sparked the backline into life
2/30 Jack Nowell 7
Given he was up against North, coped very well and showed his turn of pace on occasion
3/30 Luther Burrell 9
Scored his third try in four Tests to put England clear. Could have had a breathtaking second had he not tried to barge over Halfpenny. Outstanding nonetheless
4/30 Billy Twelvetrees 7
Coped much better with Roberts’ hard-running, and his deft kick was perfectly weighted for Burrell’s try. Grew into the game as it went on, and can be proud of his performance
5/30 Jonny May 6
His major threat seems to come on the switchback, but if given the chance to run he can definitely punish teams. Somewhat starved of ball in attacking spaces
6/30 Owen Farrell 9
Ran the show superbly in what was arguably his finest outing in the Red Rose. Perfect kicking record kept the scoreboard ticking, and he continues to develop into a fine player
7/30 Danny Care 8
Give this man space at your peril. Set-up and scored the first try from a tap-and-go, and sniped around the edges all afternoon
8/30 Joe Marler 7
Recovered from a first scrum-shock to give England a solid platform. Departed after 64 minutes after a good day’s shift
9/30 Dylan Hartley 7
Without a doubt England’s first-choice hooker. His accuracy at the lineout rivals the best in the world, and tackled his heart out today
10/30 David Wilson 8
Doesn’t look like a man two games into his comeback from injury. Departed when the game was won, and his break that set up the first try was eye-catching
11/30 Joe Launchbury 7
England have a jewel of a second-row right now, and Launchbury is only getting better. Bossed the defence and used his pace to plug the gaps. Thudding hit on Roberts defined his game
12/30 Courtney Lawes 9
His bruising reputation was boosted today with a man-of-the-match performance. Tackled anything red that moved, and even bounced off the referee at one point
13/30 Tom Wood 7
Remained quiet, but that’s exactly what you want from a top quality blindside. Work around the edges was as good as has become expected
14/30 Chris Robshaw 8
Took a few big hits but got up as always. Played his heart out and the win is a just reward for his two previous defeats against Wales
15/30 Ben Morgan 7
The absence of Billy Vunipola wasn’t felt as Morgan handled the burdon of carrying the ball very well. Made some hard yards, and bailed England out of trouble when they were on the back foot
16/30 Leigh Halfpenny 7/10
Ultra-reliable with the boot to keep Wales in the game at the break, but caught out for Burrell’s score. Defended valiantly as always, and prevented a great try with his last-ditch tackle on Burrell in the second half
17/30 Alex Cuthbert 6
Much quieter than his last outing against England. His big-game potential deserted him, and exposed in defence for the second try
18/30 Jonathan Davies 5
Looked rusty, which isn’t surprising. Dropped the ball when Wales were on the attack and was unusually outpaced at times
19/30 Jamie Roberts 6
Tried to thunder his way over the England defence, but came up against an in-form Twelvetrees who was up to the task. Ran out of ideas soon after
20/30 George North 5
Unusually quiet, and butchered two clear chances to get the Welsh across the tryline
21/30 Rhys Priestland 6
Need to develop a ‘Plan B’ as Warren Gatland has put it when Wales’ bludgeoning tactic doesn’t work. Hauled off early and could lose his place to Biggar
22/30 Rhys Webb 5
Looked star-struck on the big stage, as he was quickly warned by the referee for giving away penalties. Lost the ball in a good chance for Wales and left the field immediately after
23/30 Gethin Jenkins 5
Had success early, but was soon under pressure once Wilson and more importantly Romain Poite figured out his angling in at the scrum. His yellow card cost Wales, and he didn’t return after
24/30 Richard Hibbard 6
Carried the ball well and was a force in defence, but cracked under pressure at a crucial 5m lineout that led to Burrell’s try
25/30 Adam Jones 7
Gave Marler a hard fight in the scrum and got the better of Vunipola when he entered the affray. Struggled once England regrouped, but ultimately one of Wales’ better players
26/30 Jake Ball 6
Didn’t challenge enough of England’s ball in the air, but at 22 years old he can still develop. Left with 10 minutes to go when the game was lost
27/30 Alun Wyn Jones 6
Not as commanding as we are accustomed to, and knocked on when Wales were in the England 22m
28/30 Dan Lydiate 6
Tackled his heart out with his famed chop, but did little else in open field. Replaced by Tipuric, who has to ask what he has to do to get into the side
29/30 Sam Warburton 6
His impact on the game was felt more in his conversations with the referee as his side fell short of his whistle time-again. Tackled well, but couldn’t get his hands on the ball to have an impact
30/30 Taulupe Faletau 6
Another who fell away when the game got tough. Faletau has shown his big match temperament in the past, but this wasn’t one of his better showings
Scrum-half Rhys Webb also left the action early, limping off with a suspected ankle injury, suggesting a minimum of two changes when Gatland names his team to face Scotland on Tuesday.
There are likely to be other switches, though, such was the paucity of Wales' performance, with fly-half Rhys Priestland and prop Gethin Jenkins among those likely to be sweating on their places.
"It has been tough on these players in retrospect - a Grand Slam (2012), a championship (2013) and a Lions tour. It has been a long 18 months for those players," Gatland added.
"But this is professional sport and you've got to get yourselves up, and unfortunately we weren't as good as we can be. That is disappointing.
"Teams are pretty close in this competition. I think the four top teams are all capable of beating each other on their day if they get their performance right, and England got their performance right."
Wales beat England by a record 30-3 margin in Cardiff last season, yet they never threatened to triumph this time around as hopes of an unprecedented Six Nations title hat-trick were destroyed.
Skipper Sam Warburton said: "That game, the 30-3 last year, was just one of those games where everything clicks for you. That happens once in a blue moon.
"That happened for us last year, but this year England deserved the win."
Wales were rocked by an early Danny Care try, and they never really recovered as England ended a run of three successive defeats against their fiercest rivals.
"It was a disappointing result," Wales number eight Taulupe Faletau said.
"There were too many errors, and England capitalised and scored points. They built momentum up pretty quickly, and we couldn't quite get there.
"We are out of contention for the championship now, but we want to end with a win and on a good note next Saturday.
"Going into the championship we wanted to come away with the title, and we haven't been able to do that. It is disappointing."