England prop Mako Vunipola has been ruled out of Saturday's QBE International against New Zealand at Twickenham with a knee injury.
Vunipola missed Saturday's 31-12 victory over Argentina and the concluding match of the autumn has come too early for his return.
Joe Marler, his replacement against the Pumas, was concussed at Twickenham but could be ready in time to face the All Blacks.
"Mako won't be playing. Joe's going through the mandatory recovery for concussion, but we're hoping he'll be OK," head coach Stuart Lancaster said.
Alex Corbisiero will start against New Zealand with Marler supplying cover on the bench - if he recovers.
Scrum-half Ben Youngs has been given the all-clear from a hip complaint and Lancaster is optimistic wing Marland Yarde will recover from a hip problem of his own.
But Lancaster has revealed wing Christian Wade is "unlikely" to recover from a tight hamstring.