Manu Tuilagi and Courtney Lawes are in contention to face Wales at Twickenham on February 25 after being recalled to the England squad by interim coach Stuart Lancaster.
Tuilagi, the Leicester centre, and Northampton lock Lawes are among the 30 players who will meet up for a training camp at England's Pennyhill Park base today.
Tuilagi, one of the few success stories of England's Word Cup campaign, made his comeback from a hamstring injury in Leicester's Aviva Premiership defeat to Exeter.
Tigers fly-half Toby Flood also rejoins the England squad, having been released last week to get some game time under his belt following a knee ligament injury.
Lawes started in the back row for Northampton against Newcastle after recovering from a knee problem.
All three players will be pushing for a return to the team after missing the victories over Scotland and Italy - leaving England's coaching staff with a positive selection headache.
Lancaster must decide whether to break up the all-Saracens midfield of Owen Farrell and Brad Barritt to make room for Tuilagi and replace Charlie Hodgson with Flood.
If Lawes was to return to the second row, England would have to sacrifice either Mouritz Botha or Tom Palmer.
With no game this weekend, Palmer has been released back to Stade Francais for their Top 14 clash with Toulon at a sold-out Stade de France.
England have battled their way to results so far but against Wales they will need to offer a much greater attacking threat, which means they need to bring momentum into the game.
Tuilagi would offer a strong gain-line busting midfield presence while Ben Morgan's ball-carrying ability could get him the nod over Phil Dowson at number eight.
The 30-man squad will train until Thursday, when interim head coach Lancaster plans to make another group of players available for Premiership duty.
Meanwhile, Bath prop David Wilson has remained with his club to continue treatment on a jaw injury.