Sam Burgess has been dropped from England's matchday 23 for Saturday's final World Cup group match against Uruguay at the City of Manchester Stadium.
Burgess has been omitted from the starting XV and bench as the hosts enter the death throes of a tournament that effectively ended for them with last Saturday's 33-13 defeat by Australia.
In a possible glimpse into England's future backline, George Ford has been recalled at fly-half, Owen Farrell moves to inside centre and Henry Slade will win his second cap in the number 13 jersey.
Eight changes have been made to the starting XV toppled by the Wallabies, including scrum-half Danny Care and wing Jack Nowell making their first appearances of the World Cup.
England XV to face Uruguay: 1 Mako Vunipola, 2 Tom Youngs, 3 Dan Cole, 4 Joe Launchbury, 5 Geoff Parling, 6 James Haskell, 7 Chris Robshaw (captain), 8 Nick Easter; 9 Danny Care, 10 George Ford, 11 Jack Nowell, 12 Owen Farrell, 13 Henry Slade, 14 Anthony Watson, 15 Alex Goode
Replacements: 16 Jamie George, 17 Joe Marler, 18 David Wilson, 19 George Kruis, 20 Tom Wood, 21 Richard Wigglesworth, 22 Jonathan Joseph, 23 Mike Brown