World Rugby's chief medical officer Martin Raftery insists changes could be made to the tackle laws to reduce the risk of concussion.
The admission comes three days into the 2015 World Cup and less than a week after former Wales flanker Jonathan Thomas was forced to retire due to epilepsy that is thought to have been caused by multiple head traumas.
BBC's Panorama programme, to be screened on Monday evening, was told by Raftery that a safety review is in progress that may lead to a revision of the laws governing the tackle, the element of the game where a player is most at risk from this type of injury.
"There's no doubt that the biggest area that we think, that we know where concussion is going to occur is in the tackle, so that will help us to look at the tackle and see what we can do to make it safer," Dr Raftery said.
When asked if this means adjusting the tackle laws, Raftery replied: 'It could be. I think that my job is to identify risk and then look for solutions to the lawmakers to make the changes that will bring about protection of the athlete."
Wales 54 Uruguay 9: Player ratings
Wales 54 Uruguay 9: Player ratings
1/10 Liam Williams - 3/10
Only got his hands on the ball three times and was hammered by Uruguayan tacklers twice. Limped off with a dead leg after 35 minutes to add to Warren Gatland's injury woes.
2/10 Alex Cuthbert - 4/10
Spent most of the first half in midfield desperately searching for the ball and although he managed to get his hands on it more after the break he made very few yards and never even went close to crossing over.
3/10 Cory Allen - 8/10
It was a bitter sweet World Cup debut for Allen, who was rewarded for his superb support play and dogged determination with three first-half tries. But he limped off in the second half with a leg injury.
4/10 Hallam Amos - 8/10
Amos is unlikely to get so much room to run during the rest of the tournament and he made the most of the space. Showed impressive pace and power as well as an eagerness to offload, scored one and set up another. But he is unlikely to start against England with George North and Alex Cuthbert fit.
5/10 Rhys Priestland - 7/10
Showed moments of quality - including a brilliant chip to set up the opening try - but lacked consistency and made several unforced errors. Likely to return to the bench against England and make way for Dan Biggar.
6/10 Gareth Davies - 6/10
Has big boots to fill in the absence of Rhys Webb and he looked sharp throughout. His service was swift but he was operating behind a dominant pack and didn't really test the fringe defence until late in the second half. However, he then went on to score two late tries.
7/10 Paul James - 6/10
Made light work of his amateur opposite number in the scrum before he was taken off with a calf injury.
8/10 Samson Lee - 7/10
Looked very strong in the scrum and will be central to Wales set piece in the coming weeks after recovering from a serious ankle injury. Went over for his first international try early on but taken off at half time.
9/10 Jake Ball - 7/10
Worked very hard in the loose, made a few bruising tackles and some strong carries. Rucked with real intensity and was always quick to the clear out.
10/10 James King - 5/10
Dr James Robson, the Scottish Rugby Union's chief medical officer, adds that law changes are needed to make the game safer after injury data from the grassroots game gathered over the last couple of years revealed the number of concussions had almost doubled in that time.
"Two seasons ago we had a real push, a real initiative - we educated people that only by knowing what was happening with injury could we make a significant difference," Robson said.
"I truly believe that the doubling between that season and the following season of the number was actually down to that education.
"I strongly believe that we do need to look at the laws of the game and the way that it's played."
Five days ago Thomas, who won 67 Wales caps between 2003 and 2011 and played in two World Cups, retired on medical advice at the age of 32 after incurring a degree of brain injury.
"I've learnt a huge amount during the last few months about head trauma, seizures and epilepsy, and it would be great if I could help out in some way," Thomas said.
"I still think it's the players who need more educating about the warning signs and getting out of that 'digging in' mentality."
Concussion was identified as the most common match injury for a third successive year in the Rugby Football Union's annual injury audit for 2013-14, which was published in February.
Head trauma now constitutes 12.5 per cent of all match injuries and has increased 59 per cent on the figures published for the 2012-13 season, rising from 54 instances incurred to 86.
There were seven retirements from the sport last season due to head and neck issues, which are bracketed together and include concussion.
Experts believe that the symptoms of concussion include personality change, mood swings, depression and memory loss.