Rock legends Def Leppard will perform the pre-game show for the first of the three NFL games to be staged at Wembley this year.
The Oakland Raiders take on the Miami Dolphins on Sunday 28 September and Def Leppard, who have sold more than 100 million albums since the 1970s, will kick-off this season's matches.
Lead singer Joe Elliott said: “Having most recently visited Wembley in May to watch Sheffield United in the FA Cup semi-final, I know what the atmosphere in the ground is like for ‘our’ football so I’m really looking forward to performing there before the NFL game and of course soaking up the excitement of the actual match. I can’t wait!”
Last year Tinie Tempah and Ne-Yo performed pre-game in front of almost 80,000 people at the national stadium.
The British national anthem will be sung by best-selling soprano Laura Wright, while Isaac Slade of The Fray will be will sing the US anthem.
Some returned tickets for the opening game will go on sale at 10am on Thursday 4 September at ticketmaster.co.uk/nfl