Whitham, who is recovering from cancer, thrilled a 17,000 crowd by passing the Ducati of Terry Rymer to win the opening race by three-hundredths of a second. Race two saw the Yamaha rider, who has won five of the last six races, increase his advantage.
MacKenzie was third in both rounds while a pair of fourth places went to Michael Rutter on a Ducati. Rutter broke his right collar-bone last weekend and underwent experimental laser "welding" treatment on Friday.
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