Russell Wilson will attempt to guide the Seattle Seahawks to Super Bowl success

NFL: Seattle Seahawks to face Denver Broncos in Super Bowl

Seattle holds on to beat the San Francisco 49ers while the Broncos beat the New England Patriots to set up Super Bowl XLVIII

Tom Brady will go up against arch-rival Peyton Manning on Saturday

American Football: Cream rises to top as final battle for Super Bowl begins

It's Conference Championship weekend, and the four best teams in the NFL lock horns for a shot at the sport's ultimate prize

Sam Berns with his parents in March 2009, when he was 12 years old

Sam Berns: Teenager whose struggle with disease became the subject of an acclaimed HBO documentary

Sam Berns, who has died at the age of 17, was a teenager whose struggle with a rare genetic condition that accelerates the aging process became the subject of a television documentary. He died from complications of Hutchinson-Gilford progeria syndrome, commonly known as progeria. The Progeria Research Foundation was founded by his parents.

Anquan Boldin, right, and Quintin Mikel collide in last night’s NFC Divisional play-off

American Football: Colin Kaepernick guides wild cards San Francisco to a showdown in Seattle with top-seeded Seahawks

Niners quarterback completed 15 of 28 passes for 196 yards

Seattle, led by Russell Wilson, are favourites to win next month's Super Bowl

American Football: All eyes on rising star Russell Wilson as Seattle aim to end 35 years of hurt

For devotees of the NFL, this is as good as it gets – the divisional round of the play-offs, four games pitting the regular season’s finest against four challengers already battle-hardened by victory in last weekend’s ever-treacherous wild-card round. And in 2014 there’s an extra twist: the prospect that one of the longest, most painful droughts in US sport might be near an end.

New England Patriots quarterback Tom Brady

NFL Divisional Playoff: Indianapolis Colts v New England Patriots match preview

A look ahead to this weekend’s Divisional Playoff match at Gillette Stadium in New England

Mind games: San Diego’s quarterback Philip Rivers (centre) says his team have the right mentality to succeed

American Football: San Diego Chargers gather pace at right time for title tilt

Momentum, if not logic, favour Mike McCoy's men in Super Bowl race

Peyton Manning broke Tom Brady's record for touchdown passes in a season

NFL: Indianapolis Colts must beware a (Peyton) Manning scorned

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Pittsburgh Steelers head coach Mike Tomlin was left to reflect on what could have been after his side missed out on the play-offs

NFL: It could have been so different for Pittsburgh had luck not played such a huge part

A round-up of the final week's NFL regular season action as the play-off berth's get locked down

Quarterback Peyton Manning #18 of the Denver Broncos and quarterback Tom Brady #12 of the New England Patriots

NFL: Tom Brady v Peyton Manning is a rivalry for the ages, and Sunday proved it

A round-up of the latest events and talking points from the world of NFL

Tom Brady of the Patriots was furious after the defeat to the Panthers

NFL round-up: Regardless of the non-call, the Carolina Panthers deserved to beat the New England Patriots

A debatable non-call on Monday night will steal the headlines, but week 11 saw the gap between the haves and have-nots increase further

Head coach Joe Philbin of the Miami Dolphins
Richie Incognito has given an interview to Fox Sports

NFL: Suspended Richie Incognito explains he is ‘not a racist’ whilst fellow Miami Dolphin team-mates defend him

Offensive Linesman has given first interview since being suspended

LeGarrette Blount #29 of the New England Patriots reacts after he scored a touchdown in the second half against the Pittsburgh Steelers

NFL round-up: Hazing and health concerns aside, week nine was a watershed moment for Pittsburgh Steelers

A look at the major talking points from week nine in the NFL

Peyton Manning

NFL: Winless and undefeated - the Manning's are worlds apart

A weekly look at the biggest talking points in the NFL

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Seifeddine Rezgui: What motivated a shy student to kill 38 holidaymakers in Tunisia?

Making of a killer

What motivated a shy student to kill 38 holidaymakers in Tunisia?
UK Heatwave: Temperatures on the tube are going to exceed the legal limit for transporting cattle

Just when you thought your commute couldn't get any worse...

Heatwave will see temperatures on the Tube exceed legal limit for transporting cattle
Exclusive - The Real Stories of Migrant Britain: Swapping Bucharest for London

The Real Stories of Migrant Britain

Meet the man who swapped Romania for the UK in a bid to provide for his family, only to discover that the home he left behind wasn't quite what it seemed
Cheaper energy on the way, but it's not all sunshine and rainbows

Cheaper energy on the way, but it's not all sunshine and rainbows

Solar power will help bring down electricity prices over the next five years, according to a new report. But it’s cheap imports of ‘dirty power’ that will lower them the most
Katy Perry prevented from buying California convent for $14.5m after nuns sell to local businesswoman instead

No grace of God for Katy Perry as sisters act to stop her buying convent

Archdiocese sues nuns who turned down star’s $14.5m because they don’t approve of her
Ajmer: The ancient Indian metropolis chosen to be a 'smart city' where residents would just be happy to have power and running water

Residents just want water and power in a city chosen to be a ‘smart’ metropolis

The Indian Government has launched an ambitious plan to transform 100 of its crumbling cities
Michael Fassbender in 'Macbeth': The Scottish play on film, from Welles to Cheggers

Something wicked?

Films of Macbeth don’t always end well - just ask Orson Welles... and Keith Chegwin
10 best sun creams for body

10 best sun creams for body

Make sure you’re protected from head to toe in the heatwave
Wimbledon 2015: Nick Bollettieri - Milos Raonic has ability to get to the top but he must learn to handle pressure in big games

Nick Bollettieri's Wimbledon files

Milos Raonic has ability to get to the top but he must learn to handle pressure in big games
Women's World Cup 2015: How England's semi-final success could do wonders for both sexes

There is more than a shiny trophy to be won by England’s World Cup women

The success of the decidedly non-famous females wearing the Three Lions could do wonders for a ‘man’s game’ riddled with cynicism and greed
How to stop an asteroid hitting Earth: Would people co-operate to face down a global peril?

How to stop an asteroid hitting Earth

Would people cooperate to face a global peril?
Just one day to find €1.6bn: Greece edges nearer euro exit

One day to find €1.6bn

Greece is edging inexorably towards an exit from the euro
New 'Iron Man' augmented reality technology could help surgeons and firefighters, say scientists

'Iron Man' augmented reality technology could become reality

Holographic projections would provide extra information on objects in a person's visual field in real time
Sugary drinks 'are killing 184,000 adults around the world every year'

Sugary drinks are killing 184,000 adults around the world every year

The drinks that should be eliminated from people's diets
Pride of Place: Historians map out untold LGBT histories of locations throughout UK

Historians map out untold LGBT histories

Public are being asked to help improve the map