Russell Wilson will attempt to guide the Seattle Seahawks to Super Bowl success

NFL: Seattle Seahawks to face Denver Broncos in Super Bowl

Seattle holds on to beat the San Francisco 49ers while the Broncos beat the New England Patriots to set up Super Bowl XLVIII

Tom Brady will go up against arch-rival Peyton Manning on Saturday

American Football: Cream rises to top as final battle for Super Bowl begins

It's Conference Championship weekend, and the four best teams in the NFL lock horns for a shot at the sport's ultimate prize

Sam Berns with his parents in March 2009, when he was 12 years old

Sam Berns: Teenager whose struggle with disease became the subject of an acclaimed HBO documentary

Sam Berns, who has died at the age of 17, was a teenager whose struggle with a rare genetic condition that accelerates the aging process became the subject of a television documentary. He died from complications of Hutchinson-Gilford progeria syndrome, commonly known as progeria. The Progeria Research Foundation was founded by his parents.

Anquan Boldin, right, and Quintin Mikel collide in last night’s NFC Divisional play-off

American Football: Colin Kaepernick guides wild cards San Francisco to a showdown in Seattle with top-seeded Seahawks

Niners quarterback completed 15 of 28 passes for 196 yards

Seattle, led by Russell Wilson, are favourites to win next month's Super Bowl

American Football: All eyes on rising star Russell Wilson as Seattle aim to end 35 years of hurt

For devotees of the NFL, this is as good as it gets – the divisional round of the play-offs, four games pitting the regular season’s finest against four challengers already battle-hardened by victory in last weekend’s ever-treacherous wild-card round. And in 2014 there’s an extra twist: the prospect that one of the longest, most painful droughts in US sport might be near an end.

New England Patriots quarterback Tom Brady

NFL Divisional Playoff: Indianapolis Colts v New England Patriots match preview

A look ahead to this weekend’s Divisional Playoff match at Gillette Stadium in New England

Mind games: San Diego’s quarterback Philip Rivers (centre) says his team have the right mentality to succeed

American Football: San Diego Chargers gather pace at right time for title tilt

Momentum, if not logic, favour Mike McCoy's men in Super Bowl race

Peyton Manning broke Tom Brady's record for touchdown passes in a season

NFL: Indianapolis Colts must beware a (Peyton) Manning scorned

Devastated by injury and dumped by his beloved team, one of the NFL’s all-time great quarterbacks is back in business and breaking records

Pittsburgh Steelers head coach Mike Tomlin was left to reflect on what could have been after his side missed out on the play-offs

NFL: It could have been so different for Pittsburgh had luck not played such a huge part

A round-up of the final week's NFL regular season action as the play-off berth's get locked down

Quarterback Peyton Manning #18 of the Denver Broncos and quarterback Tom Brady #12 of the New England Patriots

NFL: Tom Brady v Peyton Manning is a rivalry for the ages, and Sunday proved it

A round-up of the latest events and talking points from the world of NFL

Tom Brady of the Patriots was furious after the defeat to the Panthers

NFL round-up: Regardless of the non-call, the Carolina Panthers deserved to beat the New England Patriots

A debatable non-call on Monday night will steal the headlines, but week 11 saw the gap between the haves and have-nots increase further

Head coach Joe Philbin of the Miami Dolphins
Richie Incognito has given an interview to Fox Sports

NFL: Suspended Richie Incognito explains he is ‘not a racist’ whilst fellow Miami Dolphin team-mates defend him

Offensive Linesman has given first interview since being suspended

LeGarrette Blount #29 of the New England Patriots reacts after he scored a touchdown in the second half against the Pittsburgh Steelers

NFL round-up: Hazing and health concerns aside, week nine was a watershed moment for Pittsburgh Steelers

A look at the major talking points from week nine in the NFL

Peyton Manning

NFL: Winless and undefeated - the Manning's are worlds apart

A weekly look at the biggest talking points in the NFL

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Prices correct as of 17 October 2014
Wilko Johnson, now the bad news: musician splits with manager after police investigate assault claims

Wilko Johnson, now the bad news

Former Dr Feelgood splits with manager after police investigate assault claims
Mark Udall: The Democrat Senator with a fight on his hands ahead of the US midterm elections

Mark Udall: The Democrat Senator with a fight on his hands

The Senator for Colorado is for gay rights, for abortion rights – and in the Republicans’ sights as they threaten to take control of the Senate next month
New discoveries show more contact between far-flung prehistoric humans than had been thought

New discoveries show more contact between far-flung prehistoric humans than had been thought

Evidence found of contact between Easter Islanders and South America
Cerys Matthews reveals how her uncle taped 150 interviews for a biography of Dylan Thomas

Cerys Matthews on Dylan Thomas

The singer reveals how her uncle taped 150 interviews for a biography of the famous Welsh poet
DIY is not fun and we've finally realised this as a nation

Homebase closures: 'DIY is not fun'

Homebase has announced the closure of one in four of its stores. Nick Harding, who never did know his awl from his elbow, is glad to see the back of DIY
The Battle of the Five Armies: Air New Zealand releases new Hobbit-inspired in-flight video

Air New Zealand's wizard in-flight video

The airline has released a new Hobbit-inspired clip dubbed "The most epic safety video ever made"
Pumpkin spice is the flavour of the month - but can you stomach the sweetness?

Pumpkin spice is the flavour of the month

The combination of cinnamon, clove, nutmeg (and no actual pumpkin), now flavours everything from lattes to cream cheese in the US
11 best sonic skincare brushes

11 best sonic skincare brushes

Forget the flannel - take skincare to the next level by using your favourite cleanser with a sonic facial brush
Paul Scholes column: I'm not worried about Manchester United's defence - Chelsea test can be the making of Phil Jones and Marcos Rojo

Paul Scholes column

I'm not worried about Manchester United's defence - Chelsea test can be the making of Jones and Rojo
Frank Warren: Boxing has its problems but in all my time I've never seen a crooked fight

Frank Warren: Boxing has its problems but in all my time I've never seen a crooked fight

While other sports are stalked by corruption, we are an easy target for the critics
Jamie Roberts exclusive interview: 'I'm a man of my word – I'll stay in Paris'

Jamie Roberts: 'I'm a man of my word – I'll stay in Paris'

Wales centre says he’s not coming home but is looking to establish himself at Racing Métro
How could three tourists have been battered within an inch of their lives by a burglar in a plush London hotel?

A crime that reveals London's dark heart

How could three tourists have been battered within an inch of their lives by a burglar in a plush London hotel?
Meet 'Porridge' and 'Vampire': Chinese state TV is offering advice for citizens picking a Western moniker

Lost in translation: Western monikers

Chinese state TV is offering advice for citizens picking a Western moniker. Simon Usborne, who met a 'Porridge' and a 'Vampire' while in China, can see the problem
Handy hacks that make life easier: New book reveals how to rid your inbox of spam, protect your passwords and amplify your iPhone

Handy hacks that make life easier

New book reveals how to rid your email inbox of spam, protect your passwords and amplify your iPhone with a loo-roll
KidZania lets children try their hands at being a firefighter, doctor or factory worker for the day

KidZania: It's a small world

The new 'educational entertainment experience' in London's Shepherd's Bush will allow children to try out the jobs that are usually undertaken by adults, including firefighter, doctor or factory worker