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Sian Smith: 'She's not in trouble. We just want her back'

A demonstration shows how the iKnife can slice through animal muscle

Surgical 'smart' knife that detects tumours could curb spread of cancer

A surgical knife that can detect when it is cutting through cancerous tissue is being tested in hospitals, raising hopes that the spread of cancer left behind after surgery could soon be curbed more successfully.

London in the 18th Century, By Jerry White

A century – and city – of duels, dung and gin cocktails

Almacantar revives flat plans for Centre Point

The owner of London's infamous concrete tower, Centre Point, will relaunch £350m plans to transform the 1960s-built block into luxury flats within weeks.

Lavazza joins coffee revolution with roll-out of shops

Italian coffee giant Lavazza plans to open nearly 400 shops over the next decade across the UK, in the latest sign of the British public’s seemingly insatiable demand for their daily caffeine hit.

Mary Dejevsky: Don't fall for commuter sob stories

If there is anything more infuriating than the predictable New Year fare increases on public transport, it is the equally predictable whingeing on the part of suburban rail commuters. Year after year they complain that they are uniquely victimised because they don't have a choice. They are captive passengers, crammed every day into obsolete rolling stock, sitting ducks for above-inflation fare rises.

Mark Lancaster, who claimed to work as an 'assessor' for SponsorAScholar.co.uk

Detectives investigating 'sex for tuition fees' website arrest man on suspicion of inciting prostitution

Detectives investigating a website offering to pay the tuition fees of female students in return for sex have arrested a man on suspicion of inciting prostitution.

Gary Glitter arrested over Savile affair – and other stars begin to worry

The pop star Gary Glitter has become the first person to be arrested by detectives investigating allegations of multiple sex attacks by the BBC presenter Jimmy Savile.

Thieves steal paintings worth £250m

Audacious thieves stole seven paintings worth a total of £250m from a Rotterdam museum in one of the biggest art raids in recent history.

Bookshops open early to launch JK Rowling's The Casual Vacancy

Bookshops opened their doors early today for readers to get their hands on JK Rowling's first novel for adults.

Everybody's talking about...An Incident At The Border

Trafalgar Studios 2, London

Further delays hit Tube services

Tube travellers suffered a series of hold-ups today - just days before the start of the Olympics.

Lack of sand caused train to overrun station

A runaway commuter train overshot a station by two-and-a-half miles because it did not have any sand on board to help with braking in poor weather.

'Cold case' rapist jailed

An unlicensed cab driver was jailed for five years at the Old Bailey today for raping a passenger nearly 17 years ago.

Sometimes I Laugh Like My Sister, Finborough Theatre, London

Rebecca Peyton describes the moment she knew her sister had died with this unholy, guttural noise from the back of her throat.

DVD: Mademoiselle Chambon (PG)

Any love story about pained longing at a train station will inevitably draw comparisons to classic David Lean/Noel Coward romance, Brief Encounter.

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Pompeii, Capri & the Bay of Naples
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Lake Garda, Venice & Verona
Spain
Prices correct as of 23 January 2015
Isis hostage crisis: Militant group stands strong as its numerous enemies fail to find a common plan to defeat it

Isis stands strong as its numerous enemies fail to find a common plan to defeat it

The jihadis are being squeezed militarily and economically, but there is no sign of an implosion, says Patrick Cockburn
Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action

Virtual reality: Seeing is believing

Virtual reality thrusts viewers into the frontline of global events - and puts film-goers at the heart of the action
Homeless Veterans appeal: MP says Coalition ‘not doing enough’

Homeless Veterans appeal

MP says Coalition ‘not doing enough’ to help
Larry David, Steve Coogan and other comedians share stories of depression in new documentary

Comedians share stories of depression

The director of the new documentary, Kevin Pollak, tells Jessica Barrett how he got them to talk
Has The Archers lost the plot with it's spicy storylines?

Has The Archers lost the plot?

A growing number of listeners are voicing their discontent over the rural soap's spicy storylines; so loudly that even the BBC's director-general seems worried, says Simon Kelner
English Heritage adds 14 post-war office buildings to its protected lists

14 office buildings added to protected lists

Christopher Beanland explores the underrated appeal of these palaces of pen-pushing
Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

Human skull discovery in Israel proves humans lived side-by-side with Neanderthals

Scientists unearthed the cranial fragments from Manot Cave in West Galilee
World War Z author Max Brooks honours WW1's Harlem Hellfighters in new graphic novel

Max Brooks honours Harlem Hellfighters

The author talks about race, legacy and his Will Smith film option to Tim Walker
Why the league system no longer measures up

League system no longer measures up

Jon Coles, former head of standards at the Department of Education, used to be in charge of school performance rankings. He explains how he would reform the system
Valentine's Day cards: 5 best online card shops

Don't leave it to the petrol station: The best online card shops for Valentine's Day

Can't find a card you like on the high street? Try one of these sites for individual, personalised options, whatever your taste
Diego Costa: Devil in blue who upsets defences is a reminder of what Liverpool have lost

Devil in blue Costa is a reminder of what Liverpool have lost

The Reds are desperately missing Luis Suarez, says Ian Herbert
Ashley Giles: 'I'll watch England – but not as a fan'

Ashley Giles: 'I'll watch England – but not as a fan'

Former one-day coach says he will ‘observe’ their World Cup games – but ‘won’t be jumping up and down’
Greece elections: In times like these, the EU has far more dangerous adversaries than Syriza

Greece elections

In times like these, the EU has far more dangerous adversaries than Syriza, says Patrick Cockburn
Holocaust Memorial Day: Nazi victims remembered as spectre of prejudice reappears

Holocaust Memorial Day

Nazi victims remembered as spectre of prejudice reappears over Europe
Fortitude and the Arctic attraction: Our fascination with the last great wilderness

Magnetic north

The Arctic has always exerted a pull, from Greek myth to new thriller Fortitude. Gerard Gilbert considers what's behind our fascination with the last great wilderness