David Prosser: Pushing the pills may be the world's most risky business

Outlook Just who would be chief executive of a major pharmaceuticals business? Andrew Witty, the man in the hot seat at GlaxoSmithKline, may cut a confident public figure, co-opted by the Prime Minister on to an advisory panel of business's great and good, but he also has to spend a disproportionate amount of time looking over his shoulder. For Mr Witty runs a leading company in an industry that is right in the sights of regulators worldwide.

Investment Column: GSK is healthy, and it's not just the drugs

Unilever; RPS Group

GSK buyback eyed after Quest sale

GlaxoSmithKline stoked hopes that it might restart its share buyback programme last night after announcing the sale of its stake in Quest Diagnostics in a $1.7bn (£802m) deal.

Mark Dampier: Interest rate rise would spell economic disaster

Many column inches have been devoted to inflation and interest rates during the last couple of weeks. With inflation above target for such a long time, pressure is growing on the Bank of England to consider an interest rate rise. According to Neil Woodford, manager of Invesco Perpetual Income and High Income, two of the largest funds in the country, this would be a big mistake. He points out a high oil price of $90 a barrel has a big impact on the UK, but in the longer term it has a deflationary rather than inflationary effect. Non-discretionary inflation effectively acts as an extra tax, depressing demand. He believes an interest rate rise would be disastrous for an economy where there is little sign of wage increases and consumers are faced with utility bill rises of 25 per cent or more in the next five to seven years. I agree it is hard to see how the UK consumer would cope with higher mortgage rates on top of everything else.

GSK sets aside £2.2bn to cover Avandia claims

Legal bills related to diabetes drug will wipe out profits for the past quarter

Cancer drug set for NHS fast-track

A new drug to treat advanced kidney cancer has been fast-tracked for use on the NHS, a health watchdog said yesterday.

Business Diary: Casting aspersions on our bosses

Marc Bolland, the boss of Marks & Spencer, Eric Daniels, the chief executive of Lloyds Banking Group, and Andrew Witty, the top man at GlaxoSmithKline, ought to consult their lawyers. Illicitencounters.com, the rather tacky website that puts professionals seeking a bit of extramarital fun in touch with each other, made its most insulting announcement yet yesterday. It has apparently offered 60 bosses of FTSE 100 companies – in particular, it namechecks Bolland, Daniels and Witty – free membership of the site, "encouraging them to cheat online". What on earth is it suggesting about these respectable gentlemen?

Glaxo pledges to invest £500m in UK after 'patent box' reforms

GlaxoSmithKline plans to invest more than £500m in manufacturing projects in the UK after the Chancellor, George Osborne, backed the previous government's plans for a lower 10 per cent corporate tax rate on profits from newly commercialised patents.

Glaxo to pay out $750m over impure drugs lawsuit

In a rare public humiliation for a British company in the United States, GlaxoSmithKline last night formally agreed to pay $750m (£473m) to settle criminal and civil complaints stemming from a whistleblower's revelations about a shockingly degraded factory in Puerto Rico.

David Prosser: Two measures that raise doubts about Coalition's 'business-friendly' pledge

Outlook There was something of a love-in at the Confederation of British Industry (CBI) conference, with a bevy of ministers down to say how much they loved business and some sweeties to share in the form of big speeches and big announcements. No wonder. Business leaders are being courted because they are desperately needed to help to fill the gap created by George Osborne's 500,000 job cuts.

Business chiefs back George Osborne deficit cut strategy

Chancellor George Osborne's deficit reduction strategy today won backing from the private sector with a letter of support signed by 35 business leaders.

Arts and Entertainment
Game Of Thrones
Uh-oh, winter is coming. Ouch, my eyes! Ygritte’s a goner. Lysa’s a goner. Tywin’s a goner. Look, a dragon
tvSpoiler warning: The British actor says viewers have 'not seen the last' of his character
Arts and Entertainment
'New Tricks' star Dennis Waterman is departing from the show after he completes filming on two more episodes
tvOnly remaining original cast-member to leave long-running series
Esteban Cambiasso makes it 3-3
premier league
The Etihad Stadium, home of Manchester City
premier leaguePlus updates from Everton vs Palace
people'I hated him during those times'
Britain's shadow chancellor Ed Balls (L) challenges reporter Rob Merrick for the ball during the Labour Party versus the media soccer match,
peopleReporter left bleeding after tackle from shadow Chancellor in annual political football match
Heskey's aim has improved since the end of his English football career

Long after his career in English football has ended, Emile Heskey's impotency in front of goal remains an object of ridicule.

Dame Vivienne Westwood has been raging pretty much all of her life
peopleFirst memoir extracts show she 'felt pressured' into going out with the Sex Pistols manager
Career Services

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Independent Travel
Languedoc Roussillon
Marrakesh & the Atlas Mountains
The Jura Mountains
Dubrovnik & the Dalmatian Coast
Prices correct as of 17 September 2014
Scottish referendum: The Yes vote was the love that dared speak its name, but it was not to be

Despite the result, this is the end of the status quo

Boyd Tonkin on the fall-out from the Scottish referendum
Manolo Blahnik: The high priest of heels talks flats, Englishness, and why he loves Mary Beard

Manolo Blahnik: Flats, Englishness, and Mary Beard

The shoe designer who has been dubbed 'the patron saint of the stiletto'
The Beatles biographer reveals exclusive original manuscripts of some of the best pop songs ever written

Scrambled eggs and LSD

Behind The Beatles' lyrics - thanks to Hunter Davis's original manuscript copies
'Normcore' fashion: Blending in is the new standing out in latest catwalk non-trend

'Normcore': Blending in is the new standing out

Just when fashion was in grave danger of running out of trends, it only went and invented the non-trend. Rebecca Gonsalves investigates
Dance’s new leading ladies fight back: How female vocalists are now writing their own hits

New leading ladies of dance fight back

How female vocalists are now writing their own hits
Mystery of the Ground Zero wedding photo

A shot in the dark

Mystery of the wedding photo from Ground Zero
His life, the universe and everything

His life, the universe and everything

New biography sheds light on comic genius of Douglas Adams
Save us from small screen superheroes

Save us from small screen superheroes

Shows like Agents of S.H.I.E.L.D are little more than marketing tools
Reach for the skies

Reach for the skies

From pools to football pitches, rooftop living is looking up
These are the 12 best hotel spas in the UK

12 best hotel spas in the UK

Some hotels go all out on facilities; others stand out for the sheer quality of treatments
These Iranian-controlled Shia militias used to specialise in killing American soldiers. Now they are fighting Isis, backed up by US airstrikes

Widespread fear of Isis is producing strange bedfellows

Iranian-controlled Shia militias that used to kill American soldiers are now fighting Isis, helped by US airstrikes
Topshop goes part Athena poster, part last spring Prada

Topshop goes part Athena poster, part last spring Prada

Shoppers don't come to Topshop for the unique
How to make a Lego masterpiece

How to make a Lego masterpiece

Toy breaks out of the nursery and heads for the gallery
Meet the ‘Endies’ – city dwellers who are too poor to have fun

Meet the ‘Endies’ – city dwellers who are too poor to have fun

Urbanites are cursed with an acronym pointing to Employed but No Disposable Income or Savings
Paisley’s decision to make peace with IRA enemies might remind the Arabs of Sadat

Ian Paisley’s decision to make peace with his IRA enemies

His Save Ulster from Sodomy campaign would surely have been supported by many a Sunni imam