Baroness Thatcher believed that Britain should withdraw from the European Union but was persuaded by her advisors to remain silent, it emerged.

The prospect of Sir John Major speaking on any subject is an inviting one, given his transformation from much-derided Prime Minister to all-but-perfect elder statesman. Even more so when the debate is on so emotive a topic as Britain, Europe, and David Cameron’s promise to re-write the rules and then put it to a vote.

The Wellcome Collection's Death: A Self-Portrait is far from morbid. Rather, the colourful, inventive and fun artworks make for an approachable, even life-affirming, show, as Adrian Hamilton discovers

The Tory parliamentary party is more Eurosceptic now than ever before

There's nothing the House of Commons likes more than to relive the battles of the past. As Dennis Skinner put it during yesterday's Europe debate, it was "almost a replay" of the great crisis over the Maastricht Treaty nearly 20 years ago. Earlier, Ed Miliband had ominously, if crudely, invoked that heady period by telling David Cameron that he was "weak abroad... weak at home. It is John Major all over again".

A Tory veteran of the party's internal squabbling over Europe says that the EU may be a nightmare, but the only pragmatic approach is to engage with it intelligently

A ban on foreign tourists buying marijuana came into effect in parts of the Netherlands today, with a protest planned in the southern city of Maastricht.

Villa Augustus, Dordrecht

A Dutch scientist has made 'meat' from stem cells – and wants Heston Blumenthal to cook the first batch. By Steve Connor

A Dutch scientist has created 'meat' from stem cells – and wants Heston Blumenthal to cook the first batch. Steve Connor reports on the ultimate in culinary experimentation

What is a right-minded liberal to make of Britain's sudden isolation in Europe? First, a confession. Along with pro-European political leaders, and along with other pro-European newspapers, we may have been too forgiving of the naive and idealistic, and not forgiving enough of those who questioned the way in which the European elite pursued the goal of ever closer union.

And that stands for?

Drivers scrambled for banknotes on a busy road in the Netherlands yesterday after a package containing euro bills fell from a bank's lorry and broke open.

Female non-smokers who eat a Mediterranean diet, exercise and keep a healthy weight could live up to 15 years longer, researchers say. Meanwhile, men who follow a similarly healthy regime could add eight years to their lifespans, according to academics at Maastricht University in the Netherlands.