Charlie Sheen and Selma Blair together in 2012

Charlie Sheen is at it again. The volatile actor is reportedly up to his old tricks having allegedly fired co-star Selma Blair from his sitcom Anger Management via an expletive-filled text message.

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AstraZeneca pays $1.2bn for lung treatment maker

AstraZeneca has bought the US lung drug specialist Pearl Therapeutics for $1.15bn (£740m) as it continues to resuscitate its product pipeline through deals.

A multiple sclerosis sufferer receiving physiotherapy

Scientists proclaim MS treatment breakthrough after dramatic test results - but with small group so far

Therapy involves extracting patient's white blood cells that are mixed with proteins and re-infused

DVD & Blu-ray review: Wreck-It Ralph (PG)

Rich Moore DVD/ Blu-ray (108mins)

European Court of Human Rights rejects Christians' cases that their religious rights were violated by employers

Three British Christians who claimed their religious rights were violated by employers were told by European judges today that they could take their rejected cases no further.

Call for hotline serving grown-up victims of child abuse

Call follows wave of victims coming forward in the wake of the Jimmy Savile scandal

Pirsig: A survival guide for the soul

Invisible Ink: No 173 - Robert M Pirsig

In the roll-call of student summer reading certain volumes stand out, including Desmond Morris's body language phenomenon The Naked Ape and Richard Bach's Jonathan Livingston Seagull. To those can be added a volume by Robert M Pirsig that snuggled its way into every hitchhiker's hand-crocheted body satchel. Unlike Bach, whose books were like being hit with a wiffle bat full of pot-pourri, Pirsig is the real deal. Born in 1928, this precocious university student was eventually expelled for studying too hard, after growing bewildered by the choice of multiple hypotheses in his chosen field, biochemistry. Overwhelmed by the limitations of science, he tackled Eastern philosophy instead, spending time in India before returning to a US college.

Abode with me: Galway's House Hotel

Going for it in Galway

The Hedonist: What to see and where to be seen

A colour enhanced MRI image of the brain shows one of the theories into what may be the chemical basis for Schizophrenia. Researchers have found reduced receptors for dopamine in the brain (areas colourized)

We need to change the way we talk about schizophrenia

If we only ever talk about schizophrenia in the context of a violent murder, is it any surprise that the public think people with mental illness are dangerous?

Sketch: It's panto time again… and starring a saints and sinners performance

Aviva AGMs are usually like Christmas pantos: they come round once a year, feature heroes and (mostly) villains and the audience always enjoys taking part.

GTA 5: Rockstar release 3 new character trailers for Michael, Franklin and Trevor

Rockstar has released trailers that show each of the three main characters from Grand Theft Auto 5.

The Sound of One Hand Killing, By Teresa Solana

Teresa Solana is already known to us, as are her terrible twins, through two previous crime novels. Again translated by Peter Bush, The Sound of One Hand Killing is, however, the first in the series in which Solana and her twin Barcelona private eyes, Borja ("Pep") and Eduard Masdeu, actually meet on the page.

Lance Armstrong used a post-dated medical note to explain away positive tests

Cycling: Lance Armstrong failed four drugs tests in 1999, UCI admits

The International Cycling Union has defended its actions after it was confirmed that Lance Armstrong returned test samples with traces of corticosteroids four times during the 1999 Tour de France.

Reflexology may be as effective as painkillers, according to researchers at the University of Portsmouth

Use reflexology to complement drugs in pain treatment, survey findings suggest

Reflexology may be as effective as painkillers, according to a new scientific survey.

Studies find heart can affect how we feel fear

Fear may be felt in the heart as well as the head, according to a study that has found a link between the cycles of a beating heart and the likelihood of someone taking fright.

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Martin Stephen: 'Ofsted says comprehensives are failing the most able but teaching bright children isn't rocket science'

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Jenson Button: Downbeat driver cannot wait to put season behind him

Jenson Button: Downbeat driver cannot wait to put season behind him

McLaren man admits 'failed gamble' with car has left him pinning hopes on 2014 campaign
James Lawton: Firmer fist will be required to win Champions Trophy final battle with stouter foe

James Lawton

Firmer fist will be required to win Champions Trophy final battle with stouter foe
'To farm I have to rape the countryside. It’s got to be wrong': The true effect of the badger cull

The true effect of the badger cull

'To farm I have to rape the countryside. It’s got to be wrong'
Theatre review: Daniel Radcliffe gives an admirably honest performance in Michael Grandage's The Cripple of Inishmaan

First night: The Cripple of Inishmaan

Daniel Radcliffe gives an admirably honest performance in Michael Grandage's comedy
Girls Guides drop religious reference but pledge to self and the Queen

Guides drop religious reference but pledge to self and the Queen

After 103 years, organisation changes oath to welcome 'all girls, of all faiths, and none'
Steve Tongue: Joe Kinnear was one of the boys and a breath of fresh air... 21 years ago

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Chris Froome: Free from 'pain in neck' after Bradley Wiggins' exit

Chris Froome: Free from 'pain in neck' after Wiggins' exit

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