El Otro Lado: Portobelo
This colourful retreat is on the "other side" of the bay of Portobelo, opposite the city once prized by the Spaniards as a silver port and attacked by Henry Morgan. The hotel's four villas burst with tropical hues, set against the lush forest backdrop of Chagres National Park. Inside, Arte Povera meets mid-century Modernism, with patterned tiles and local artwork. Caribbean fusion cuisine is served at the poolside Gazebo.
El Otro Lado, Portobelo Bay, Colón (00 507 202 01 11; elotrolado.com.pa). Doubles start at US$490 (£306), including breakfast.