Heavy snow has closed the M6 motorway in both directions after lorries jacknifed across carriageways while flooding in other areas of the country has led to various traffic problems.
The M6 is closed between southbound between junction 27 at Wigan and junction 25 following a severe snow storm, while the northbound carriageway is also reported to be closed.
North Yorkshire Fire Service said a couple had to be rescued from a snow drift on the Yorkshire Moors.
It was not only roads affected as Manchester Airport was forced to close its runway for over an hour while crews worked to clear it of snow. Flights in and out of Leeds Bradford Airport were also suspended.
The Met Office has issued 12 amber warnings from the Midlands up to central England, and the public are urged to prepare for likely disruption caused by heavy snow.
As snow begins to melt in other areas across the UK and heavy rain begins to set in, weather experts have warned about flooding.
Southwest Wales is one of the first regions to be hit, with emergency services responding to a rise in calls as roads and properties become flooded. The M5 is also reportedly flooded between junction 25 at Taunton and junction 26.
The Environment Agency has issued 18 flood warnings across the UK, mainly across Wales and the South West, while a further 74 areas have been told to be on alert for flooding.