1846: First successful use of anaesthetic, at Massachusetts General Hospital.
1902: The first Borstal opens in the village of Borstal, Kent.
1916: The first birth control clinic opens in the United States.
1923: In Switzerland, John Harwood patents the self-winding watch.
1928: Mary Pipkin patents the frosted light bulb.
1931: Divorce is legalised in Spain.
1860: The first professional golf tournament is held in Scotland.
1902: The first Cadillac is made in Detroit.
1826: Britain holds its last state lottery before 1994.
1865: Lord Palmerston said: "Die, my dear doctor? That's the last thing I shall do." Then he died.
1887: The US buys Alaska from Russia for $7.2m.
1927: Dancing bears are banned from the streets of Berlin.
1982: The first escape ramp for hedgehogs is installed in a cattle grid on the A117 near Ludlow, Shropshire.
1987: An American chopstick manufacturer announces the sale of 12 million pairs to Japan.
1901: Albert de Santos wins pounds 1,000 for the first airship flight around the Eiffel Tower.
1970: BP announce the first oil strike in the North Sea.
1818: The 49th parallel is established as the boundary between Canada and the United States.
1915: Women are allowed to apply for licences as bus and tram conductors in London.
1824: Portland cement is patented by Joseph Aspdin.
1868: Birth of Sir Ernest Dunlop Swinton, the originator of the word "tank" for an armoured vehicle.
1958: The first life peers are introduced into the House of Lords.
1960: Launch of Dreadnought, Britain's first nuclear submarine.
1797: Andre-Jacques Garnerin makes the first successful descent by parachute, from a balloon 6,000ft above Paris.
1903: Publication in London of the National Temperance Manifesto.
1909: Elise Deroche becomes the first woman to fly solo.
1910: Dr Crippen is convicted of murdering his wife.