The Australian singer, 24, attacked the rapper on Twitter for the controversial lyrics, which feature on his upcoming compilation album Shady XV.
“If I let you run alongside the Humvee. Unless you’re Nicki [Minaj], grab you by the wrist, let’s ski,” Eminem raps.
“So what’s it gon’ be? Put that s**t away Iggy. You don’t wanna blow that rape whistle on me. Scream! I love it. ‘Fore I get lost with the gettin’ off.”
Iggy responded angrily to her misogynistic name drop, adding that Eminem’s reference was “awkward” as her younger brother is a fan.
Other disturbing “Vegas” lyrics include: “B***h, shut the f**k up and get in my car. And suck my f**king d**k while I take a s**t.”
But Iggy is not the only female artist to be mentioned in Eminem’s songs. “Summertime Sadness” singer Lana Del Rey is attacked in “Shady Cxvpher”, with Eminem violently talking of punching her “right in the face twice”, while Christina Aguilera, Britney Spears, the Olsen twins, Mariah Carey, Amy Winehouse, Lindsay Lohan and Kim Kardashian have all been rapped about before.
Iggy is set to perform at the American Music Awards on Sunday with Jennifer Lopez. She became embroiled in a Twitter feud with Snoop Dogg last month, when the rapper mocked her appearance.
He uploaded multiple degrading Instagram posts, including some making jokes about her race, before posting an expletive-filled video for her in which he says: “Say b***h, you’re f**king with the wrong n***a and your n***a better check you before I do you funky b***h. Yeah, you. F**king c**t.”
Iggy addressed the attack, writing: “Why would you post such a mean pic to insta when you send your body guards to ask me for pictures every time we are at shows together?
“Every time I’ve ever spoken to you you’ve always been nice as hell. I’m disappointed you’d be such an ass for no reason.”
She later compared Snoop to “the guy that asks for your number and then says you ugly and a b***h when you say no”.
He eventually apologised for his cruel words after talking to fellow rapper T.I. "No more bad talk, I apologize, I apologize," he said. "I'm sorry, I won't do it again."
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