The singer partnered with GLSEN [the Gay, Lesbian and Straight Education Network) to help launch clubs for LGBT+ youth in American high schools.
Commenting on the new venture in a statement, Urie said: "For years my fans have inspired me with their determination and creativity as they have created a safe and inclusive community.
"I felt the time had come for me to join them boldly, to bring that energy and power to bear on the huge challenges facing our whole society."
Urie's partnership follows his creation of the Higher Hopes Foundation, which will support human rights advocacy across marginalised communities.
The record just hit No.1 in the US and No.2 in the UK. It sold 180,000 copies in its first week of release, marking the best sales week for an alternative rock album since U2's Songs of Experience was released in December 2017.
Panic! At The Disco are set to headline Reading + Leeds festivals in the UK, 24-26 August.
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