More research into the root causes of food allergies is vital
More research into the root causes of food allergies is vital

Severe food allergies are more common than ever, and scientists can’t figure out why

From excessively clean environments to increased use of soy, many hypotheses have been put forward to try and explain rising allergy rates – but the truth is we just don’t know what’s causing it

Monday 17 December 2018 15:39

The inquest into the death of Natasha Ednan-Laperouse from anaphylaxis after eating a Pret A Manger baguette she was unaware contained sesame, could lead to a change in food labelling legislation. A recent investigation found undeclared allergens were present in a quarter of foods sampled. But a more fundamental issue needs to be addressed: why are more people experiencing severe food allergies than ever before?

As I explain in Another Person’s Poison: A History of Food Allergy, strange reactions to food have long been known. Ancient Greek physician Hippocrates (c.460-370BC) described such reactions to various foods, including cheese. Strawberries caused Richard III to break out into hives. It is said he once sneakily consumed “a messe of strauberies”, and then blamed his reaction on witchcraft orchestrated by a rival, who was summarily beheaded.

By the time Austrian physician Clemens von Pirquet coined the term “allergy” in 1906, many believed food could trigger skin problems, asthma, gastrointestinal distress and even mental disorders.

In the 1930s, food allergy emerged as a distinctive sub-category of allergy but it was highly controversial. Although it was easy to identify the food at fault in anaphylactic reactions, such as the one that killed Ms Ednan-Laperouse, such sudden reactions were rare. Food allergists tended to focus instead on patients whose reactions were delayed, occurring up to 48 hours after eating the suspected food and thus much more difficult to diagnose. Such reactions were typified by symptoms such as eczema, diarrhoea, asthma, migraine and psychiatric problems, including depression and hyperactivity.

Many doctors, however, doubted the claims of specialists that food allergy was responsible for much undiagnosed chronic illness. Some were so unconvinced they would refer patients complaining of chronic food allergy to psychiatrists, believing their symptoms psychosomatic. The heated debates that would emerge during the post-war period about the prevalence of food allergy distracted researchers from investigating the root causes of the condition.

Enter the peanut

In the early 1980s, food allergy became a marginalised topic within medicine. Then, a new phenomenon emerged that forced doctors to take it seriously: peanut allergy. In 1988, an article in the Canadian Medical Association Journal described the case of a 24-year-old woman who died after eating a biscuit containing peanut oil. Although one or two similar stories had been reported previously, it was the first report made in a medical journal. It would not be the last.

By the 1990s, peanut allergy fatalities were commonplace. According to US charity Food Allergy Research and Education (Fare), rates of peanut and tree nut allergy tripled between 1997 and 2008 among American children. As a result, food allergy became associated with severe, potentially fatal reactions, rather than the chronic food allergies on which food allergists had previously concentrated.

Fare and other allergy charities successfully lobbied for better labelling, more peanut-free spaces – in schools for instance – and the availability of life-saving epipens which administer a dose of epinephrine, a chemical that narrows blood vessels and opens airways in the lungs, to anyone suffering an anaphylactic reaction.

But they failed to convince scientists to conduct detailed investigations into why such allergies were increasing so rapidly. On one hand, the reluctance was understandable. There was a pressing need to provide new treatments and support to the increasing number of people suffering severe food allergies. On the other, scientists were hesitant to investigate a condition that had long been considered a fad – a suspicious and divisive diagnosis that was too reliant on patient accounts for its justification.

While research continues to explore potential cures and treatments, not enough effort has been spent on exploring root causes. A number of controversial explanations have been suggested as a result, many of which have not been based on much scientific research.

Possible explanations

One suggestion is the hygiene hypothesis, which argues children grow up in excessively clean environments, ensuring their bodies struggle to distinguish between harmful pathogens and harmless proteins such as those found in peanuts. Others point to cooking techniques, and point out peanut allergy is more common in countries where peanuts are roasted rather than boiled.

Infant feeding is also implicated, the most recent advice being that mothers with a family history of allergy should introduce peanuts early on. The increased use of soya – a relative of the peanut – in food production has also been suggested. But none of these explanations have proved completely convincing, leading to the emergence of even more controversial hypotheses.

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The truth is, we simply don’t yet know what is triggering the peanut allergy epidemic or increasing rates of food allergy. A chief reason is a lack of open-minded research into the causes of allergy. The explanations that emerge from such research might not be easy for people to accept if they indicate food allergy is a byproduct of modern lifestyles, new diets or changes in how people interact with their environment.

Investigating the causes of food allergy will not be easy, but if medicine is to prevent more tragedies such as that of teenager Ms Ednan-Laperouse, it will be essential.

Matthew Smith is a senior lecturer in history at the University of Strathclyde. This article first appeared on The Conversation (

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