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Leaving the EU would be a "colossal mistake" but the UK will one day decide to rejoin the bloc, Sir John Major has said.
The former Conservative prime minister said he believed young people would overturn Brexit and form a new alliance with European countries in the future, as the younger generation preferred "cooperation to separation."
His comments come amid fresh uncertainty over the Brexit process, as EU leaders consider whether to offer Boris Johnson another extension to the UK's departure from the bloc.
The prime minister is facing a choice between making another attempt to pass his Brexit deal legislation and pushing for an early general election amid speculation of a possible poll before Christmas.
Sir John, who has campaigned for a Final Say referendum, took part in a successful legal challenge against Mr Johnson's decision to suspend parliament for several weeks in September.
Best pictures from Final Say Brexit marchShow all 76 1 /76Best pictures from Final Say Brexit march Best pictures from Final Say Brexit march Crowds march through central London
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Best pictures from Final Say Brexit march Protesters gather in Parliament Square
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Best pictures from Final Say Brexit march Mayor of London Sadiq Khan joins protesters
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Best pictures from Final Say Brexit march Anti-Brexit protesters fill Parliament Square in London
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march A demonstrator marches
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Best pictures from Final Say Brexit march
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Best pictures from Final Say Brexit march Protesters push a float depicting Dominic Cummings using Boris Johnson as a puppet during the Final Say Brexit march in London
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Best pictures from Final Say Brexit march EU supporters react after the result of the vote on the deal delay was announced at the House of Commons
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Best pictures from Final Say Brexit march A demonstrator carries his dog draped in EU flag
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Best pictures from Final Say Brexit march Thousands of people taking part in a People's Vote march
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Best pictures from Final Say Brexit march Protesters use their flags to shelter from the rain
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Best pictures from Final Say Brexit march Protesters march towards Parliament Square
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Best pictures from Final Say Brexit march Anti-Brexit demonstrators carry placards and EU flags
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Best pictures from Final Say Brexit march Sir Oliver Letwin MP in Parliament Square, London, during an an anti-Brexit, Let Us Be Heard rally, after it was announced that the Letwin amendment, which seeks to avoid a no-deal Brexit on October 31, has been accepted
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Best pictures from Final Say Brexit march Thousands of people taking part in a People's Vote march
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Best pictures from Final Say Brexit march A protester with "Bollocks to Brexit" stickers on his head
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Best pictures from Final Say Brexit march Demonstrators march
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Best pictures from Final Say Brexit march Britain's main opposition Labour Party shadow Secretary of State for Exiting the EU Keir Starmer, shadow Home Secretary Dianne Abbott, shadow Chancellor of the Exchequer John McDonnell, shadow Foreign Secretary Emily Thornberry speaks on stage in Parliament Square
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Best pictures from Final Say Brexit march Anti-Brexit supporters cheer outside parliament
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Best pictures from Final Say Brexit march A EU supporter waves flags
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Best pictures from Final Say Brexit march Anti-Brexit supporters
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Best pictures from Final Say Brexit march Protesters shout and chant demanding a final say
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Best pictures from Final Say Brexit march Pro-Brexit protesters outside the Houses of Parliament in London
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Best pictures from Final Say Brexit march People taking part in an Anti-Brexit, Let Us Be Heard march head to Parliament Square in London
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Best pictures from Final Say Brexit march People taking part in an Anti-Brexit, Let Us Be Heard march in Trafalgar Square
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Best pictures from Final Say Brexit march Anti-Brexit supporters cheer outside parliament
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Best pictures from Final Say Brexit march People taking part in an Anti-Brexit, Let Us Be Heard march past Trafalgar Square
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Best pictures from Final Say Brexit march Protesters shout and chant
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Best pictures from Final Say Brexit march Cory (7) sits on his father's shoulders as protesters march towards Parliament Square
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Best pictures from Final Say Brexit march People attend the 'Together for the Final Say' march
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Best pictures from Final Say Brexit march Protesters march towards Parliament Square
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Best pictures from Final Say Brexit march Mayor of London Sadiq Khan speaks on stage
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Best pictures from Final Say Brexit march Anti-Brexit protesters fill Parliament Square in London
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Best pictures from Final Say Brexit march Anti-Brexit protesters hold an Independent banner
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Best pictures from Final Say Brexit march Protesters hold an anti-Brexit placard by The Independent stall during the Final Say Brexit march in London
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Best pictures from Final Say Brexit march Anti-Brexit protesters in Parliament Square, London,
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Best pictures from Final Say Brexit march Demonstrators hold placards and EU flags
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Best pictures from Final Say Brexit march An anti-Brexit protester joins in the Final Say Brexit march on 19 October
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Best pictures from Final Say Brexit march EU supporters march in London
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Best pictures from Final Say Brexit march Sir Patrick Stewart and Paul McGann join in the Final Say Brexit march in London on 19 October
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Best pictures from Final Say Brexit march EU supporters march
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Best pictures from Final Say Brexit march A demonstrator shouts into a megaphone as she marches
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Best pictures from Final Say Brexit march A dog dressed in an anti-Brexit placard is walked in the Final Say Brexit march in London
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Best pictures from Final Say Brexit march EU supporters march
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Best pictures from Final Say Brexit march A morris dancer takes part in the Final Say Brexit march in London
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Best pictures from Final Say Brexit march Whippets are dressed in EU flag clothing during the Final Say Brexit march in London
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Best pictures from Final Say Brexit march Protesters march towards parliament in the Final Say Brexit march in London on 19 October 2019
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Best pictures from Final Say Brexit march An anti-Brexit demonstrator takes part in the Final Say Brexit march in London
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Best pictures from Final Say Brexit march EU supporters call on the government to give Britons a vote on the final Brexit deal
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Best pictures from Final Say Brexit march Anti-Brexit protesters
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Best pictures from Final Say Brexit march An anti-Brexit protester
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Best pictures from Final Say Brexit march Anti-Brexit protesters demonstrate in London during the Final Say Brexit march on 19 October
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Best pictures from Final Say Brexit march Protesters push a float depicting Dominic Cummings using Boris Johnson as a puppet during the Final Say Brexit march in London
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Best pictures from Final Say Brexit march Protesters march towards parliament from Park Lane in the Final Say Brexit march in London on 19 October 2019
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Best pictures from Final Say Brexit march Marchers visit The Independent stall during the Final Say March in London
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Best pictures from Final Say Brexit march An anti-Brexit protester holds a sign calling for a Final Say during a march in London
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Speaking at the One Young World global forum for young leaders, he said: "Young people have been let down, they overwhelmingly wished to remain in the EU, whereas many of their elders did not.
"I have been a critic of Brexit, and I remain so. I think it's bad for the UK, bad for the EU and bad for Europe, and a colossal mistake. Other than that, I have no complaints about it."
Sir John went on: "Young people prefer cooperation to separation.
"Even the most powerful nations in the world require allies.
"In the end, the young are going to win because they will be here and the elderly won't.
Independent Minds Events: get involved in the news agenda "One day, I confidently predict, the young ones will re-enter the EU or form a new alliance with them.
"Who knows what lies ahead, but it certainly won't be conventional and it certainly won't be dull."
EU leaders are expected to decide on Friday on whether there should be another Brexit delay.
The bloc is expected to agree a "flextension" to the end of January - as set out in the prime minister's request - but with the option for the UK to leave before then if parliament approves the Brexit deal.
Mr Johnson was forced to write to EU leaders to ask for a delay due to a backbench law known as the Benn Act. However he refused to sign the letter, in an attempt to make clear it was parliament's request rather than his own.
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