De Bruyne suffered lateral ligament damage to his right knee in August, which was expected to rule him out for two to three months.
The Belgian returned to full training earlier this week, however, ahead of City’s Champions League tie in Hoffenheim.
De Bruyne continued to train with the first team throughout the week and Guardiola has now suggested he could feature at Anfield, subject to a late fitness test.
“He made part of the training today,” Guardiola said on the 27-year-old. “He’s training with us, yeah.”
Asked whether De Bruyne was in contention to play, the City manager said: “We’ll see tomorrow.”
Guardiola also confirmed that Benjamin Mendy is back in training following a spell out on the sidelines.
The full-back, who has not featured since the victory over Newcastle United in early September, could also return to play against Jürgen Klopp’s side on Sunday.
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