Others are unsuited to Mourinho's particular style of play. More still will be shipped out after failing to impress during Louis van Gaal's reign.
So who are the ten players most at risk and what are their chances of survival?
Take a look through the gallery below to see who might have to endure a few restless nights over the next few months, according to our chief football correspondent Mark Ogden.
Do you agree with our list? Did we miss any out? Who would you like to see walk out the doors of Old Trafford and never return again?
Let us know in the comments...
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