Leighton Baines failed to convert the first penalty of his Premier League career after seeing his first half effort saved by David De Gea.
Everton won the penalty when Tony Hibbert's surging run into the box was abruptly ended when Luke Shaw scythed him down.
However the visitors were unable to capitalise and get the goal that would have drawn them level with hosts Manchester United.
Baines' fairly weak effort to David De Gea's right was saved well by the Spanish keeper and ensured that the defender's run of 15 consecutive penalties scored in the Premier League came to an abrupt end.
As a result of the miss. Everton went into half time 1-0 down, thanks to Angel Di Maria's goal for the hosts.
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