He will be followed by Serena Williams, who is attempting to win at SW19 for an eighth time. She plays Italian outsider Giulia Gatto-Monticone, who is making her Wimbledon debut aged 31.
Elsewhere, new World No 1 Ashleigh Barty will begin proceedings on Court No 1 with a match against Saisai Zheng.
British number one Johanna Konta is also in action, with a first round clash against the Romanian Ana Bogdan, who has never been beyond the second round at Wimbledon.
For the full order of play, see below.
Day two order of play
All times BST, seeds in brackets
13:00: Tatjana Maria (Ger) v (5) Angelique Kerber (Ger), Lloyd George Harris (Rsa) v (2) Roger Federer (Swi), (11) Serena Williams (USA) v Giulia Gatto-Monticone (Ita)
13:00: (1) Ashleigh Barty (Aus) v Saisai Zheng (Chn), Ana Bogdan (Rom) v (19) Johanna Konta (Gbr), Yuichi Sugita (Jpn) v (3) Rafael Nadal (Spa)
11:00: (9) Sloane Stephens (USA) v Timea Bacsinszky (Swi), (5) Dominic Thiem (Aut) v Sam Querrey (USA), Maria Sharapova (Rus) v Pauline Parmentier (Fra), Casper Ruud (Nor) v (9) John Isner (USA)
11:00: Nick Kyrgios (Aus) v Jordan Thompson (Aus), Beatriz Haddad Maia (Bra) v (26) Garbine Muguruza (Spa), Ons Jabeur (Tun) v (6) Petra Kvitova (Cze), (13) Marin Cilic (Cro) v Adrian Mannarino (Fra)
11:00: Ekaterina Alexandrova (Rus) v Katerina Siniakova (Cze), (20) Gilles Simon (Fra) v Salvatore Caruso (Ita), (33) Jan-Lennard Struff (Ger) v Radu Albot (Mol)
11:00: Barbora Zahlavova Strycova (Cze) v (32) Lesia Tsurenko (Ukr), Kateryna Kozlova (Ukr) v Lauren Davis (USA), Dominik Koepfer (Ger) v Filip Krajinovic (Ser), Pablo Andujar (Spa) v Mikhail Kukushkin (Kaz)
11:00: Svetlana Kuznetsova (Rus) v Alison Van Uytvanck (Bel), Magda Linette (Pol) v Anna Kalinskaya (Rus), Yasutaka Uchiyama (Jpn) v Tennys Sandgren (USA), Guido Andreozzi (Arg) v (31) Laslo Djere (Ser)
11:00: Steve Johnson (USA) v Albert Ramos-Vinolas (Spa), Yafan Wang (Chn) v Tereza Martincova (Cze), Lesley Kerkhove (Ned) v Ivana Jorovic (Ser), Hugo Dellien (Bol) v John Millman (Aus)
11:00: (21) Elise Mertens (Bel) v Fiona Ferro (Fra), Brayden Schnur (Can) v Marcos Baghdatis (Cyp), Jay Clarke (Gbr) v Noah Rubin (USA), Anastasia Rodionova (Aus) v Taylor Townsend (USA)
11:00: Stefanie Voegele (Swi) v Kaia Kanepi (Est), Christian Garin (Chi) v Andrey Rublev (Rus), Kaja Juvan (Slo) v Kristyna Pliskova (Cze), Marton Fucsovics (Hun) v Dennis Novak (Aut)
11:00: Vera Lapko (Blr) v (15) Qiang Wang (Chn), (17) Matteo Berrettini (Ita) v Aljaz Bedene (Slo), Paula Badosa Gibert (Spa) v Varvara Flink (Rus), Alexander Bublik (Kaz) v Gregoire Barrere (Fra)
11:00: (8) Kei Nishikori (Jpn) v Thiago Moura Monteiro (Bra), Laura Siegemund (Ger) v Katie Swan (Gbr), Bernard Tomic (Aus) v Jo-Wilfried Tsonga (Fra), (4) Kiki Bertens (Ned) v Mandy Minella (Lux)
11:00: Harriet Dart (Gbr) v Christina McHale (USA), Tamara Zidansek (Slo) v Eugenie Bouchard (Can), (29) Denis Shapovalov (Can) v Ricardas Berankis (Lit), (27) Lucas Pouille (Fra) v Richard Gasquet (Fra)
11:00: Marco Cecchinato (Ita) v (25) Alex De Minaur (Aus), Vitalia Diatchenko (Rus) v Kristina Mladenovic (Fra), Matthew Ebden (Aus) v (24) Diego Sebastian Schwartzman (Arg), (22) Donna Vekic (Cro) v Alison Riske (USA)
11:00: Andrea Petkovic (Ger) v Monica Niculescu (Rom), Denis Istomin (Uzb) v Cameron Norrie (Gbr), Taylor Harry Fritz (USA) v Tomas Berdych (Cze)
11:00: James Ward (Gbr) v (18) Nikoloz Basilashvili (Geo), (25) Amanda Anisimova (USA) v Sorana Cirstea (Rom), Elena Gabriela Ruse (Rom) v (18) Julia Goerges (Ger), Joao Sousa (Por) v Paul Jubb (Gbr)
11:00: Federico Delbonis (Arg) v Daniel Evans (Gbr), Anastasia Pavlyuchenkova (Rus) v (13) Belinda Bencic (Swi), (30) Carla Suarez Navarro (Spa) v Samantha Stosur (Aus), Frances Tiafoe (USA) v (12) Fabio Fognini (Ita)
Follow the live action below:
Good morning and welcome to our live coverage of the second day of play at Wimbledon 2019.
The big story from the first day of play at The Championships is that five-time champion Venus Williams has been knocked out in the first round by 15-year-old sensation Cori Gauff.
Samuel Lovett was on Court 1 for that extraordinary match and you can read his report here:
Welcome to Day 2 of Wimbledon 2019!
It's an absolutely cracking order of play today, with big-name players and great match-ups on all the outside courts.
Those in action include: Roger Federer, Serena Williams, Rafael Nadal, Ashleigh Barty, Dominic Thiem, Angelique Kerber and Jo Konta (as well as seven other Brits in action overall).
Here's the order of play in full:
Oh so ready.
Here's a lowdown on all the Brits in action:
Federer is playing world number 86 Lloyd Harris in the second match on Centre Court.
Regardless of her tactics, former world number 1 Victoria Azarenka will be in round two after beating Alize Cornet in straight sets yesterday.
Our Wimbledon columnist Nick Bollettieri had his say on world number 2 Naomi Osaka's shock defeat in the first round yesterday...
Andy Murray's father-in-law, Nigel Sears: “When in Australia people were saying it was the end of his career or whatever, he hesitated slightly, even in the interviews. He wasn’t saying: ‘No, I have retired.’
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