When seven-times champion Federer takes on Dusan Lajovic and Djokovic faces Adam Pavlasek in round two, they will be hoping to put on an entertaining show from start to finish after Tuesday's fans were left feeling rather short-changed.
Djokovic, winner of three titles here, was leading Martin Klizan 6-3 2-0 when the injured Slovakian went up to shake hands with the Serb after calling time on the match with only 40 minutes on the clock.
Unbelievably for the Centre Court crowd, there were given a repeat performance just over an hour later when Federer's opponent Alexandr Dolgopolov also pulled out when trailing 3-6 0-3.
While the seven first-round withdrawals in the men's field left many questioning if players who are not fully fit should be allowed to start a tournament, on the women's side of the draw the competitors will be keen to live up to Agnieszka Radwanska's observation that "girls are really, really tough".
The 2012 finalist takes on American Christina McHale while last year's runner up Angelique Kerber, who has struggled to recapture the form that carried her to two grand slam titles last year, will be hoping she survives a tricky match against Belgian Kirsten Flipkens.
Follow all of the action from day four with our live blog...
Please allow a moment for the blog to load.
Hello and welcome to our live coverage of day four of The Championships!
Play begins at 11.30am, so join us then for coverage from around the courts.
Here's the order of play for today:
A number of players were left less than impressed yesterday as flying ants invaded The Championships.
Dustin Brown was even spotted eating one of the bugs...
Federer and Djokovic the headline acts
Roger Federer and Novak Djokovic are the two star attractions on day four of The Championships.
Seven-time champion Federer is third up on Centre Court against Serbia's Dusan Lajovic, while three-time winner Djokovic meets Adam Pavlasek from 1pm on Court One.
After yesterday's wins for Jo Konta and Andy Murray on Centre Court, another Briton, the 22-year-old Kyle Edmund, is in action on SW19's main court. He takes on French entertainer and 15th seed Gael Monfils from 1pm.
Stay tuned for regular updates throughout the day!
Not a bad trio
Mario Ancic and Andre Agassi put Novak Djokovic through his paces ahead of his match against Adam Pavlasek on Court One.
Dimitrov takes opener against Baghdatis
Men's 13th seed Grigor Dimitrov is a set to the good against Marcos Baghdatis on Court Two (6-3).
Meanwhile, Mischa Zverev, the 27th seed, is a set and a break up against Mikhail Kukushin (6-1 2-0).
Djokovic enters the fray
Twelve-time Grand Slam winner Novak Djokovic has been demoted from Centre Court to Court One for his second-round match against Adam Pavlasek.
Djokovic* 2-1 Pavlasek (*denotes next server)
Novak Djokovic is an early break up on Court One after breaking Adam Pavlasek in the opening game of the match.
Isner pegged back
Big-serving 23rd seed John Isner has lost the second set to Dudi Sela on a tie-break. The American won the opening set by the same method.
Monfils* 3-3 Edmund (*denotes next server)
The first break point of the match goes to Monfils but the Frenchman can't take it as his backhand pass sails wide. A volleyed winner followed by an ace wrap the game of for Edmund and keep this opening set on serve.
Join our new commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies