The Oscar-winning actress, who died from pneumonia, originally purchased the five-bedroom, eight-bathroom property in 2011 for $4.7 million.
Keaton, known as a seasoned house flipper, spent eight years personally renovating the 9,206-square-foot brick home into her 'dream home'.
The property, located in Sullivan Canyon, was the subject of her bestselling 2017 book, 'The House that Pinterest Built', and features a unique blend of industrial steel and ranch-style elements.
The home, which includes a library, a separate guest house, and an in-ground pool, had previously been on the market for $29 million before being relisted.