Hosted by Guz Khan, the event united British film, music, and TV stars with Palestinian artists, raising half a million pounds for Palestinian-led charities by the time the concert commenced.
Speakers included Holocaust survivor Stephen Kapos, journalist Yara Eid, and actor Richard Gere.
UN Special Rapporteur Francesca Albanese received a standing ovation for her address.
The concert occurred days after a UN investigation concluded that Israel had "orchestrated a genocidal campaign" in Gaza, a finding Israel dismissed as "antisemitic".