The musician was spotted filming in Milan this week, having travelled from London where she performed four sold-out shows, and is set to resume her tour in Stockholm.
This role follows Lady Gaga's appearance in 2024's Joker: Folie à Deux and a cameo in Netflix's Wednesday, for which she also released an original song.
Plot details for the sequel remain undisclosed, but it is rumoured to follow Miranda Priestly navigating the decline of print media and encountering Emily Charlton.
The highly anticipated film, which will also feature new cast members such as Simone Ashley and Lucy Liu, is scheduled for release in summer 2026.