The character of Maggie rarely speaks, with her first word famously voiced by Elizabeth Taylor in 1992.
The new episode, titled “Parahormonal Activity”, is set in the future and features a teenage Bart learning to drive.
Lohan shared a teaser clip where Maggie speaks a full sentence, expressing fear about Bart's driving.
Fans have noted the fitting nature of Lohan taking on a role previously associated with Taylor, given Lohan's portrayal of Taylor in the 2012 biopic Liz & Dick.