Speaking on The Rest Is Entertainment podcast, Cowell acknowledged that discussions around mental health and duty of care have become a much greater focus over time.
His comments follow several former contestants, including Jade Thirlwall of Little Mix, who have spoken out about experiencing mental health issues after participating in the show.
Katie Waissel, a 2010 contestant, claimed the show "ruined my life" and has since retrained as a lawyer to pursue legal action against Cowell and Syco Entertainment.
The X Factor co-producers, Fremantle, have stated they have "robust measures" in place, including a dedicated welfare team and no time limit on aftercare for contestants.