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Major study reveals the full effect of a bad night’s sleep

The study revealed that insomnia, particularly when combined with shorter-than-usual sleep, with white-matter damage in the brain
The study revealed that insomnia, particularly when combined with shorter-than-usual sleep, with white-matter damage in the brain (Getty/iStock)
  • A large US study from the Mayo Clinic has linked chronic insomnia in older adults to brain changes that accelerate the trajectory towards dementia.
  • Following 2,750 individuals aged 50 and over, researchers found that those with chronic insomnia experienced a faster decline in memory and thinking, and were 40% more likely to develop mild cognitive impairment or dementia.
  • The study revealed that insomnia, particularly when combined with shorter-than-usual sleep, was associated with higher levels of amyloid plaques and white-matter damage in the brain.
  • The impact of chronic insomnia on cognitive decline was found to be comparable to the effect of carrying the ApoE4 gene, a strong genetic risk factor for late-onset Alzheimer's.
  • Experts emphasise that maintaining good sleep quality from midlife is a sensible brain-health strategy, though further research is needed to confirm if treating insomnia directly prevents dementia.
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