Consuming excessive watermelon can lead to digestive issues, particularly for individuals with irritable bowel syndrome, due to its high FODMAP content.
The fruit contains tyramine, an amino acid that may trigger migraine headaches in susceptible people.
In rare instances, watermelon can cause severe allergic reactions in those sensitive to grasses or ragweed.
Its natural sugar content, around 17 grams per serving, means people with diabetes should moderate their intake.
Combining watermelon with certain depression medications can dangerously elevate blood pressure due to its tyramine levels.