It follows the Liverpudlian’s emotional retirement from MMA in March after suffering back-to-back defeats in the UFC.
McCann, who was the first British female fighter to compete in the UFC and achieved a 14-8 record, is now aiming to become a world champion within eight boxing fights.
Matchroom promoter Eddie Hearn has expressed confidence in McCann's boxing abilities, highlighting her amateur pedigree despite her successful MMA career.
The specific details regarding McCann's first professional boxing bout, including her opponent and the date, are yet to be confirmed by either McCann or Matchroom.