Melvyn Bragg will delve into the nativity story and mental health, while Sir James Dyson will explore Britain's inventive streak and progress towards a dementia cure.
Cate Blanchett's broadcast will examine AI's impact on women in film and fashion sustainability, with Mustafa Suleyman challenging listeners on a post-superintelligence world.
Baroness May will address themes of domestic violence and trust in politics, and Tom Holland will celebrate England's 1,100th birthday and discuss AI's influence on academic research.