Amy Jones (129 off 76 balls) and Tammy Beaumont (106) both scored centuries for the second consecutive game, setting a strong foundation for England's victory.
England set a target of 367 runs, which proved too challenging for West Indies, especially with the absence of star player Hayley Matthews due to a shoulder injury.
Realeanna Grimmond made a half-century on her ODI debut, but West Indies struggled to maintain momentum, losing their final six wickets for 69 runs.
Alice Capsey starred with three wickets, and Kate Cross picked up her 100th ODI wicket, contributing to West Indies' collapse and England's dominant win.