The US singer will play Grizabella when the Andrew Lloyd Webber musical returns for a limited run at the end of the year.
Scherzinger said she was honoured to take part in the musical in what will be her West End debut.
She said: “To have the opportunity to work with Andrew, Trevor and Gillian is a dream come true. I grew up listening to Andrew’s extraordinary music and was lucky enough, a couple of years ago, to record Cats’ beautiful song ‘Memory’.”
The former X Factor UK judge added: “Andrew’s score is breathtaking and I am truly honoured to have been asked to take part in what I know will be a very special time in my career. I can’t wait to begin rehearsals.”
Based on TS Eliot’s Old Possum’s Book of Practical Cats, the musical will return to the West End stage at the Palladium on 6 December.
Directed by Trevor Nunn and choreographed by Gillian Lynne, Cats first opened at the New London Theatre in 1981, where it played for 21 years.
It won numerous awards, picking up Best Musical at both the Oliviers and the Tonys.
Cats opened on Broadway in 1982 and ran for 18 years. It went on to become the second longest-running show in Broadway history after The Phantom of the Opera.
Independent Partners: tickets for Cats are available through ViagogoReuse content