Cells to restore eyesight are grown in lab and transplanted into blind mice

Artificial photoreceptors integrated into retina after being transplanted into blind mice

The prospect of restoring the sight of blind people with stem-cell transplants has come a step closer with a study showing that it is possible to grow the light-sensitive cells of the eye in a dish with the help of an artificial retina, scientists said.

For the first time, researchers have not only grown the photoreceptors of the eye in the laboratory from stem cells but transplanted them into eyes of blind mice where the cells have become fully integrated into the complex retinal tissue.

So far the scientists have been unable to show any improvement in the vision of the blind mice – but they are confident that this will soon be possible in further experiments, which should enable them to move to the first clinical trials on patients within five years.

Professor Robin Ali of University College London, who led the research at the Institute of Ophthalmology and Moorfields Eye Hospital, said that the technique could lead to stem cell transplants for improving the vision of thousands of people with degenerative eye disorders caused by the progressive loss of photosensitive cells.

“The breakthrough here is that we’ve demonstrated we can transplant photoreceptors derived from embryonic stem cells into adult mice. It paves the way to a human clinical trial because now we have a clear route map of how to do it,” Professor Ali said.

The loss of photosensitive cells, the rods and cones of the retina, is a leading cause of sight loss in a number of degenerative eye diseases, such as age-related macular degeneration, retinitis pigmentosa and diabetes-related blindness.

Professor Ali and his team extracted stem cells from mouse embryos and grew them into light-sensitive rod cells with the help of an artificial retina growing in a laboratory dish. This allowed the rod cells to develop the complex three-dimensional structure that is important for them to function correctly.

“Over recent years scientists have become pretty good at working with stem cells and coaxing them to develop into different types of adult cells and tissues. But until recently the complex structure of the retina has proved difficult to reproduce in the lab,” Professor Ali said.

“The new 3D technique more closely mimics normal development, which means we are able to pick out and purify the cells at precisely the right stage to ensure successful transplantation. The next step will be to refine this technique using human cells to enable us to start clinical trials,” he said.

A separate clinical trial with embryonic stem cells is already under way in Britain and the United States to treat Stargardt’s disease, an incurable eye condition where there is a loss of the retinal cells that support and protect the light-sensitive cells.

The study, published in the journal Nature Biotechnology and funded by the Medical Research Council, involved the transplant of about 200,000 artificially grown rod cells into the retinas of night-blind mice, which lacked the rod cells that provide vision in low-light conditions.

PROMOTED VIDEO
Arts and Entertainment
Rita Ora will replace Kylie Minogue as a judge on The Voice 2015
tv
Life and Style
tech
Life and Style
Alan Turing, who was convicted of gross indecency in 1952, was granted a royal pardon last year
life
Arts and Entertainment
Sheridan Smith as Cilla Black and Ed Stoppard as her manager Brian Epstein
tvCilla Episode 2 review: Grit under the glamour in part two of biopic series starring Sheridan Smith
Life and Style
life
Arts and Entertainment
Tennis player Andy Murray's mum Judy has been paired with Anton du Beke for Strictly Come Dancing. 'I'm absolutely delighted,' she said.
tvJudy Murray 'struggling' to let Anton Du Beke take control on Strictly
Life and Style
Vote with your wallet: the app can help shoppers feel more informed about items on sale
lifeNew app reveals political leanings of food companies
News
ebooksAn unforgettable anthology of contemporary reportage
Arts and Entertainment
The cover of Dark Side of the Moon
musicCan 'The Endless River' carry on the tradition? See for yourself
Sport
New Zealand fly-half Aaron Cruden pictured in The Zookeeper's Son on a late-night drinking session
rugby
Extras
indybest
Voices
A new app has been launched that enables people to have a cuddle from a stranger
voicesMaybe the new app will make it more normal to reach out to strangers
Arts and Entertainment
Salmond told a Scottish television chat show in 2001that he would also sit in front of a mirror and say things like,
tvCelebrity Trekkies from Alex Salmond to Barack Obama
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

IT Project manager - Web E-commerce

£65000 Per Annum Benefits + bonus: Clearwater People Solutions Ltd: If you are...

PSHE Teacher - Chester

Negotiable: Randstad Education Chester: Teachers with a passion for PSHE neede...

Humanities Teacher

£85 - £125 per day: Randstad Education Chester: Job Opportunity for Secondary ...

PSHE Teachers needed for exciting project

Negotiable: Randstad Education Chester: Teachers with a passion for PSHE neede...

Day In a Page

Secret politics of the weekly shop

The politics of the weekly shop

New app reveals political leanings of food companies
Beam me up, Scottie!

Beam me up, Scottie!

Celebrity Trekkies from Alex Salmond to Barack Obama
Beware Wet Paint: The ICA's latest ambitious exhibition

Beware Wet Paint

The ICA's latest ambitious exhibition
Pink Floyd have produced some of rock's greatest ever album covers

Pink Floyd have produced some of rock's greatest ever album covers

Can 'The Endless River' carry on the tradition?
Sanctuary for the suicidal

Sanctuary for the suicidal

One mother's story of how London charity Maytree helped her son with his depression
A roller-coaster tale from the 'voice of a generation'

Not That Kind of Girl:

A roller-coaster tale from 'voice of a generation' Lena Dunham
London is not bedlam or a cradle of vice. In fact it, as much as anywhere, deserves independence

London is not bedlam or a cradle of vice

In fact it, as much as anywhere, deserves independence
Vivienne Westwood 'didn’t want' relationship with Malcolm McLaren

Vivienne Westwood 'didn’t want' relationship with McLaren

Designer 'felt pressured' into going out with Sex Pistols manager
Jourdan Dunn: Model mother

Model mother

Jordan Dunn became one of the best-paid models in the world
Apple still coolest brand – despite U2 PR disaster

Apple still the coolest brand

Despite PR disaster of free U2 album
Scottish referendum: The Yes vote was the love that dared speak its name, but it was not to be

Despite the result, this is the end of the status quo

Boyd Tonkin on the fall-out from the Scottish referendum
Manolo Blahnik: The high priest of heels talks flats, Englishness, and why he loves Mary Beard

Manolo Blahnik: Flats, Englishness, and Mary Beard

The shoe designer who has been dubbed 'the patron saint of the stiletto'
The Beatles biographer reveals exclusive original manuscripts of some of the best pop songs ever written

Scrambled eggs and LSD

Behind The Beatles' lyrics - thanks to Hunter Davis's original manuscript copies
'Normcore' fashion: Blending in is the new standing out in latest catwalk non-trend

'Normcore': Blending in is the new standing out

Just when fashion was in grave danger of running out of trends, it only went and invented the non-trend. Rebecca Gonsalves investigates
Dance’s new leading ladies fight back: How female vocalists are now writing their own hits

New leading ladies of dance fight back

How female vocalists are now writing their own hits