New hope for spinal injuries: scientists have 're-grown' cells in paralysed rats - Science - News - The Independent

New hope for spinal injuries: scientists have 're-grown' cells in paralysed rats

 

US scientists have reported a major breakthrough on the road to treating spinal injuries that result in paralysis.

Paralysed rats were able to re-gain some bladder control after undergoing surgery to transplant nerve cells into the spinal cord.

Surgery was then combined with series of chemical injections. After three, and again at six months, the scientists discovered that rats who had received this combination of treatment showed bladder function again.

Achieving cell growth after they have been transplanted has always proved difficult for scientists because of the scar tissue damaged cells produce as they respond to injury.

Instead Yu-Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others used a chemical that promotes cell growth and reduces scarring, creating an environment that cells are more likely to connect in.

This special “glue” boosts cell growth and breaks down scar tissue, encouraging the cells to regenerate.

The researchers found for the first time that injured nerve cells could re-grow for “remarkably long distances” of approximately 2cm, raising hopes for treating paralysed patients in the future.

Yu-Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others noted that whilst the animals did not regain the ability to walk, they did regain “a remarkable measure of urinary control".

“This is the first time that significant bladder function has been restored via nerve regeneration after a devastating cord injury,” Lee added.

“What was especially surprising and exciting was that a subset of nerve cells situated largely in the brainstem could slowly re-grow far down the spinal cord once a permissive environment that allowed them past the site of the scar was provided.

“What endows these particular neurons with such an innately high re-growth capacity is unknown but will be an extremely important area of research in the future.”

The study was published in the 26 June edition of the Journal of Neuroscience.

Life and Style
tech
Arts and Entertainment
Robin Thicke's video for 'Blurred Lines' has been criticised for condoning rape
music
News
Paper trail: the wedding photograph found in the rubble after 9/11 – it took Elizabeth Keefe 13 years to find the people in it
newsWho are the people in this photo? It took Elizabeth Stringer Keefe 13 years to find out
Arts and Entertainment
Evil eye: Douglas Adams in 'mad genius' pose
booksNew biography sheds light on comic genius of Douglas Adams
PROMOTED VIDEO
Sport
FootballFull debuts don't come much more stylish than those on show here
Arts and Entertainment
Fringe show: 'Cilla', with Sheridan Smith in the title role and Aneurin Barnard as her future husband Bobby Willis
tvEllen E Jones on ITV's 'Cilla'
News
i100
Sport
Tim Wiese
sport
Life and Style
Kim Kardashian drawn backlash over her sexy swimsuit selfie, called 'disgusting' and 'nasty'
fashionCritics say magazine only pays attention to fashion trends among rich, white women
Arts and Entertainment
TVShows like Agents of S.H.I.E.L.D are little more than marketing tools
Arts and Entertainment
Hit the roof: hot-tub cinema east London
architectureFrom pools to football pitches, rooftop living is looking up
Travel
travel
News
ebooksAn unforgettable anthology of contemporary reportage
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Data/ MI Analyst

£25000 - £30000 Per Annum: Clearwater People Solutions Ltd: Our client are cur...

Project Manager (retail, upgrades, rollouts)

£40000 - £45000 Per Annum + benefits: Clearwater People Solutions Ltd: Project...

Project Manager (upgrades, rollouts, migrations)

£350 - £425 Per Day: Clearwater People Solutions Ltd: Project Manager - 3 mont...

DT Teacher -Key stage 3 all areas

£120 - £130 per day: Randstad Education Chelmsford: We are seeking a DT teache...

Day In a Page

Mystery of the Ground Zero wedding photo

A shot in the dark

Mystery of the wedding photo from Ground Zero
His life, the universe and everything

His life, the universe and everything

New biography sheds light on comic genius of Douglas Adams
Save us from small screen superheroes

Save us from small screen superheroes

Shows like Agents of S.H.I.E.L.D are little more than marketing tools
Reach for the skies

Reach for the skies

From pools to football pitches, rooftop living is looking up
These are the 12 best hotel spas in the UK

12 best hotel spas in the UK

Some hotels go all out on facilities; others stand out for the sheer quality of treatments
These Iranian-controlled Shia militias used to specialise in killing American soldiers. Now they are fighting Isis, backed up by US airstrikes

Widespread fear of Isis is producing strange bedfellows

Iranian-controlled Shia militias that used to kill American soldiers are now fighting Isis, helped by US airstrikes
Topshop goes part Athena poster, part last spring Prada

Topshop goes part Athena poster, part last spring Prada

Shoppers don't come to Topshop for the unique
How to make a Lego masterpiece

How to make a Lego masterpiece

Toy breaks out of the nursery and heads for the gallery
Meet the ‘Endies’ – city dwellers who are too poor to have fun

Meet the ‘Endies’ – city dwellers who are too poor to have fun

Urbanites are cursed with an acronym pointing to Employed but No Disposable Income or Savings
Paisley’s decision to make peace with IRA enemies might remind the Arabs of Sadat

Ian Paisley’s decision to make peace with his IRA enemies

His Save Ulster from Sodomy campaign would surely have been supported by many a Sunni imam
'She was a singer, a superstar, an addict, but to me, her mother, she is simply Amy'

'She was a singer, a superstar, an addict, but to me, her mother, she is simply Amy'

Exclusive extract from Janis Winehouse's poignant new memoir
Is this the role to win Cumberbatch an Oscar?

Is this the role to win Cumberbatch an Oscar?

The Imitation Game, film review
England and Roy Hodgson take a joint step towards redemption in Basel

England and Hodgson take a joint step towards redemption

Welbeck double puts England on the road to Euro 2016
Relatives fight over Vivian Maier’s rare photos

Relatives fight over Vivian Maier’s rare photos

Pictures removed from public view as courts decide ownership
‘Fashion has to be fun. It’s a big business, not a cure for cancer’

‘Fashion has to be fun. It’s a big business, not a cure for cancer’

Donatella Versace at New York Fashion Week