Radical new therapy to tackle baldness is just a hair’s breadth away after discovery
Growing new hair follicles from human skin cells raises hopes not just for people with conventional hairloss but also those with alopecia and burns damage
Steve Connor is the Science Editor of The Independent. He has won many awards for his journalism, including five-times winner of the prestigious British science writers’ award; the David Perlman Award of the American Geophysical Union; twice commended as specialist journalist of the year in the UK Press Awards; UK health journalist of the year and a special merit award of the European School of Oncology for his investigative journalism. He has a degree in zoology from the University of Oxford and has a special interest in genetics and medical science, human evolution and origins, climate change and the environment.
Tuesday 22 October 2013
An effective treatment for chronic hair loss in both men and women has come a step closer with a study showing that it is possible to grow new hair follicles from human skin cells.
The results promise to break a 40-year deadlock in attempts to regenerate the crucial structures in the skin that cause hair to grow, which could lead to radically different therapies for treating unwanted baldness, especially in women.
Human hair follicles have proved notoriously difficult to replicate in the laboratory, but a new technique has shown that they can be stimulated to grow in skin tissue and made to produce hair shafts.
Instead of simply transplanting hair follicles from one part of the body to another - which is how hair transplants are currently carried out - a patient's own skin tissue could be used to produce virtually unlimited quantities of follicles for hair-transplant operations, scientists said.
An Anglo-American team of researchers believes the research represents a "milestone advance" in the attempt to stimulate active hair growth in people suffering from chronic hair loss, such as burns victims and women with alopecia, as well as male baldness.
"This approach has the potential to transform the medical treatment of hair loss," said Professor Angela Christiano of Columbia University in New York, one of the lead authors of the study published in the journal Proceedings of the National Academy of Sciences.
"Current hair-loss medications tend to slow the loss of hair follicles or potentially stimulate the growth of existing hairs, but they do not create new hair follicles. Neither do conventional hair transplants, which relocate a set number of hairs from the back of the scalp to the front," Professor Christiano said.
"Our method, in contrast, has the potential to actually grow new follicles using a patient's own cells. This could greatly expand the utility of hair-restoration surgery to women and to younger patients - now it is largely restricted to the treatment of male-pattern baldness in patients with stable disease," she said.
About nine out of ten women with serious hair loss cannot undergo conventional hair transplants because they do not have enough of the necessary hair follicles elsewhere in the body. This new method could generate large numbers of new hair follicles, or regenerate existing follicles, from just a few hundred donor hairs, Professor Christiano said.
"It could make hair transplantation available to individuals with a limited number of follicles, including those with female-pattern hair loss, scarring alopecia and hair loss due to burns," she said.
Specialised cells called the dermal papillae can be induced to form hair follicles in laboratory rats but the same process has evaded scientists working on human dermal papillae for 40 years, said Professor Colin Jahoda of Durham University, the co-leader of the study.
Human dermal papilla cells do not respond in the same way as rat cells when grown in conventional, flat culture dishes. But when they are grown in three-dimensional "spheroids" - drops hanging down from a glass slide - they can be re-programmed into dermal papillae that can trigger the formation of hair follicles when transplanted into human skin grown on the backs of mice, Professor Jahoda said.
Seven patients donated skin cells for the research and in five cases the resulting hair follicles caused the regrowth of human hair on the back of the experimental mice which lasted for at least six weeks, he said.
"It's a key step because it is saying that you can multiply the process. It's not just about one-for-one replacement. But you need to get hair that is the right colour and texture and this will need further work before human clinical trials can begin," he said.
"We also think that this study is an important step toward the goal of creating a replacement skin that contains hair follicles for use with, for example, burn patients," he said.
Wellcome Image Awards: The most striking images from the world of science, including breast cancer cells under chemical attack and a photographer’s own kidney stone
Missing Malaysia Airlines plane: Terrorism explanation 'cannot be ruled out', says CIA
Bob Crow death: 'Admired by his members, feared by employers' - Tributes pour in for RMT union leader and 'working class hero' Bob Crow
Oscar Pistorius murder trial: Athlete repeatedly sick as court hears 'graphic details' of Reeva Steenkamp's post-mortem
How climate change helped Genghis Khan: Scientists believe a sudden period of warmer weather allowed the Mongols to invade with such success
Britain's top vet sparks controversy with call for ban on slashing animals' throats in 'ritual' slaughters for halal and kosher meat products
Exclusive: Impact of immigrants on British workers ‘negligible’
Katie Hopkins continues campaign to become Britain's most hated talking head with poorly timed Bob Crow tweet
Ukraine crisis: Russia pledges to 'retaliate against sanctions' as Ukrainian president says Crimea vote will not be recognised
The quiet diplomat: Catherine Ashton - recognised and admired in all the world’s troubled countries, yet ridiculed at home
Grace Dent: Who cares if she spells it Barraco Barner? Gemma Worrall is more employable than some bookish arts graduate
- 1 Bad cattitude: Family call police after crazed and 'hostile cat with a history of violence' attacks baby before attempting to 'flee custody'
- 2 Family forced to flee home after discovering 'terrifying' nest of spiders in bananas
- 3 First Kiss: Filmmaker gets 20 strangers to make out on YouTube with awkward results
- 4 Grace Dent: Who cares if she spells it Barraco Barner? Gemma Worrall is more employable than some bookish arts graduate
- 5 Bob Crow death: 'Admired by his members, feared by employers' - Tributes pour in for RMT union leader and 'working class hero' Bob Crow
£20000 - £25000 per annum: Inspiring Interns: One of the largest mobile advert...
£20000 - £23000 per annum: Inspiring Interns: Our client specialises in creati...
£30000 - £50000 per annum + Very Competitive Salary: Austen Lloyd: Private Cli...
£30000 - £35000 per annum + Very Competitive Salary: Austen Lloyd: Residential...