Scientists create new flu vaccine that works against many different strains of the virus

New treatment developed by fusing key proteins of the virus with a bacterial protein

A new kind of flu vaccine that works against many different strains of influenza virus has proved to be more effective than conventional vaccines at stimulating the immune defences of laboratory ferrets, the standard animal “model” of the human infection, a study has found.

Scientists made the vaccine by fusing key proteins of the flu virus, made synthetically by genetic engineering technology, with a bacterial protein called ferritin that can automatically assemble itself into “nanoparticles” smaller than the virus. The flu proteins, which stick out from the ferritin like the spikes on a sea mine, stimulate immunity against the virus.

Normally, influenza vaccines are made by culturing live virus in hens' eggs, a risky and time-consuming procedure, but the new method was simpler and it produced a vaccine that appears to generate immunity to a wide range of flu viruses rather than being restricted to just one strain, scientists said.

The study, published in Nature, by a team led by Gary Nabel of the US National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, said that the new vaccine could lead to broader immunity against new types of influenza viruses and other kinds of infectious agents that threaten to cause global epidemics.

“Standard vaccines rapidly lose efficacy, because the influenza virus is constantly mutating into new, unpredictable strains. The new vaccine works by stimulating the production of neutralising antibodies that latch on to parts of the virus that are common to different strains, which is a step towards the realization of a much sought-after universal vaccine,” says a statement from Nature.

“Made entirely from recombinant ingredients, it is also safer to make than standard vaccines, which are produced by growing the virus in eggs or cultured cells,” Nature says.

Professor Sarah Gilbert, a vaccine expert at Oxford University, said: “Overall, the study shows that it is possible to achieve broader immunity to influenza than that obtained with licensed influenza vaccines, which is an important step in the right direction, but there is a long way to go before this will make a difference to protecting people against influenza.”

Start your day with The Independent, sign up for daily news emails
ebooks
ebooksAn introduction to the ground rules of British democracy
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
SPONSORED FEATURES
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Recruitment Genius: Office / Sales Manager

£22000 - £32000 per annum: Recruitment Genius: Established and expanding South...

Recruitment Genius: Administrative Assistant / Order Fulfilment

£14000 per annum: Recruitment Genius: An exciting opportunity to join a thrivi...

SThree: Trainee Recruitment Consultant

£18000 - £23000 per annum + Uncapped OTE: SThree: Trainee Recruitment Consulta...

SThree: Trainee Recruitment Consultant

£18000 - £23000 per annum + Uncapped OTE: SThree: Trainee Recruitment Consulta...

Day In a Page

Refugee crisis: David Cameron lowered the flag for the dead king of Saudi Arabia - will he do the same honour for little Aylan Kurdi?

Cameron lowered the flag for the dead king of Saudi Arabia...

But will he do the same honour for little Aylan Kurdi, asks Robert Fisk
Our leaders lack courage in this refugee crisis. We are shamed by our European neighbours

Our leaders lack courage in this refugee crisis. We are shamed by our European neighbours

Humanity must be at the heart of politics, says Jeremy Corbyn
Joe Biden's 'tease tour': Could the US Vice-President be testing the water for a presidential run?

Joe Biden's 'tease tour'

Could the US Vice-President be testing the water for a presidential run?
Britain's 24-hour culture: With the 'leisured society' a distant dream we're working longer and less regular hours than ever

Britain's 24-hour culture

With the 'leisured society' a distant dream we're working longer and less regular hours than ever
Diplomacy board game: Treachery is the way to win - which makes it just like the real thing

The addictive nature of Diplomacy

Bullying, betrayal, aggression – it may be just a board game, but the family that plays Diplomacy may never look at each other in the same way again
Lady Chatterley's Lover: Racy underwear for fans of DH Lawrence's equally racy tome

Fashion: Ooh, Lady Chatterley!

Take inspiration from DH Lawrence's racy tome with equally racy underwear
8 best children's clocks

Tick-tock: 8 best children's clocks

Whether you’re teaching them to tell the time or putting the finishing touches to a nursery, there’s a ticker for that
Charlie Austin: Queens Park Rangers striker says ‘If the move is not right, I’m not going’

Charlie Austin: ‘If the move is not right, I’m not going’

After hitting 18 goals in the Premier League last season, the QPR striker was the great non-deal of transfer deadline day. But he says he'd preferred another shot at promotion
Isis profits from destruction of antiquities by selling relics to dealers - and then blowing up the buildings they come from to conceal the evidence of looting

How Isis profits from destruction of antiquities

Robert Fisk on the terrorist group's manipulation of the market to increase the price of artefacts
Labour leadership: Andy Burnham urges Jeremy Corbyn voters to think again in last-minute plea

'If we lose touch we’ll end up with two decades of the Tories'

In an exclusive interview, Andy Burnham urges Jeremy Corbyn voters to think again in last-minute plea
Tunisia fears its Arab Spring could be reversed as the new regime becomes as intolerant of dissent as its predecessor

The Arab Spring reversed

Tunisian protesters fear that a new law will whitewash corrupt businessmen and officials, but they are finding that the new regime is becoming as intolerant of dissent as its predecessor
King Arthur: Legendary figure was real and lived most of his life in Strathclyde, academic claims

Academic claims King Arthur was real - and reveals where he lived

Dr Andrew Breeze says the legendary figure did exist – but was a general, not a king
Who is Oliver Bonas and how has he captured middle-class hearts?

Who is Oliver Bonas?

It's the first high-street store to pay its staff the living wage, and it saw out the recession in style
Earth has 'lost more than half its trees' since humans first started cutting them down

Axe-wielding Man fells half the world’s trees – leaving us just 422 each

However, the number of trees may be eight times higher than previously thought
60 years of Scalextric: Model cars are now stuffed with as much tech as real ones

60 years of Scalextric

Model cars are now stuffed with as much tech as real ones