Scientists identify genetic 'enhancers' that control facial development in mice
Research might one day help us mitigate facial defects in humans
Research studying facial development in mice has given scientists new insights into the genetic controllers that determine the appearance of human faces.
An international team of scientist identified more than 4,000 small regions in the DNA that appear to influence facial features, noting that even small changes to these so-called ‘enhancers’ had “subtle but significant effects” on the shape of the face and the skull.
Although the research was carried out on mice, the scientists involved believe that many of their findings will also be applicable to humans.
"We're trying to find out how these instructions for building the human face are embedded in human DNA,” said Professor Axel Visel of the Joint Genome Institute at the Lawrence Berkeley National Laboratory in California, to the BBC.
"Somewhere in there there must be that blueprint that defines what our face looks like."
The ‘enhancers’ in question are short strings of DNA that function as switches for genes. The team of scientists experimented by turning three of these genes on and off in mice embryo, and then studying how the animals developed.
"In the mouse embryos we can see where exactly, as the face develops, this switch turns on the gene that it controls,” said Professor Visel.
A CT scan from the study showing the facial and cranial development of a mouse.
However, once the mice had matured the scientists found it difficult to detect the slight differences in the facial and cranial structure – although these might have been readily apparent to other mice.
They worked around this by taking CT scans of the mice and comparing them with none genetically-altered specimens. The changes were subtle, but showed a range of changes in the skull in both width and length.
"What this really tells us is that this particular switch also plays a role in development of the skull and can affect what exactly the skull looks like," said Professor VIsel.
It’s hoped that the research will help understanding of how and why facial defects such as cleft palates develop in the womb, perhaps allowing scientists in the future to identify and even mitigate these conditions.
However, Professor Visel also stressed that these developments would not lead to the custom designing of human faces in the near future, and that the genetic processes that determine facial appearances are many times more complex than the crude ‘on/off’ switches of these genetic ‘enhancers’.
'Fine Tuning of Craniofacial Morphology by Distant-Acting Enhancers' is published in Science
- 1 Tidal launch: The most pretentious lines from Alicia Keys' valedictory speech
- 2 Trevor Noah: Jon Stewart's replacement faces online criticism over 'anti-Semitic' tweets
- 3 Martha Stewart accuses Snoop Dogg of 'smoking for four hours' during Justin Bieber Roast
- 4 Gamers confess the worst things they've done in The Sims
- 5 Syrian child photographed 'surrendering to camera because she thought it was a gun'
Costa Concordia: Shipment of Mob drugs was hidden aboard cruise liner when it hit rocks off Italian coast, investigators say
Martha Stewart accuses Snoop Dogg of 'smoking for four hours' during Justin Bieber Roast
University of Cambridge: Remains of 1,300 scholars are found under building
Jeremy Clarkson 'could be given minder' ahead of a potential Top Gear return
Turkey power cut: Prime Minister says nationwide blackout could be caused by terrorists
Ukip supporters are 55 or older, white and socially conservative, finds British Social Attitudes Report
Street preacher quoting from the Bible fined for calling homosexuality an 'abomination'
Woman filmed launching racist tirade against men on the Tube for speaking in 'own lingo'
The West has it totally wrong on Lee Kuan Yew
David Cameron calls Labour 'hopeless, sneering socialists' while announcing 7-day NHS plans
Revealed: Putin's army of pro-Kremlin bloggers
£22500 - £30000 per annum + Commission: SThree: Sthree are looking for experie...
£16575 - £18785 per annum: Recruitment Genius: This Dundee based butchers requ...
Negotiable: Recruitment Genius: To effectively manage a team which is responsi...
Negotiable: Recruitment Genius: A rare and exciting role has arisen within thi...