Study shows dangers of BPA chemical used in plastic packaging

Bisphenol A is used to line drinks cans and in tests affected the way genes work in the brains of laboratory rats

Further evidence has emerged showing that a chemical used widely in plastic packaging and the lining of drinks cans may be harmful to health.

The latest study has shown that bisphenol A (BPA) can affect the way genes work in the brains of laboratory rats, although other scientists have questioned the relevance of the findings to humans.

Researchers found that feeding BPA to pregnant rats was associated with lasting alterations to the “epigenetic” structure of genes in the brain tissue of their offspring, causing possible changes to certain aspects of sex-specific behaviour, such as chasing, sniffing and aggression.

Previous studies on laboratory animals have also pointed to a possible link between BPA and ill health but this research was criticised by other experts for using very high doses of the chemical, which would not be relevant to levels of human exposure, and to injecting the substance rather than feeding it through the diet, which is how BPA enters the human body.

The latest study by Frances Champagne of Columbia University in New York, published in the Proceeding of the National Academy of Sciences, used what the scientists said were “environmentally relevant” doses of BPA, which were fed to the rats through their diet.

The researchers concluded: “This study provides evidence that low-dose maternal BPA exposure induces long-lasting disruption to epigenetic pathways in the brain of offspring….Importantly, our findings indicate that these BPA-induced changes occur in a sex-specific, brain region-specific and dose-dependent manner.”

Professor Richard Sharpe of the Medical Research Council's Centre for Reproductive Health in Edinburgh said that although the study is well conducted there are still problems that make it difficult to extrapolate the findings to human health.

“Whilst these findings raise the possibility that comparable effects of bisphenol A could occur in humans, several factors suggest this is unlikely. First, the lowest dose used is still 10-20 times higher than normal human bisphenol A exposure,” Professor Sharpe said.

Another problem is that there were large variations in the results beween individual animals, making reproducible results questionable. A third issue was the suggestion that BPA works by interfering with the female hormone oestrogen, as oestrogen levels are much higher in pregnant women than in pregnant mice, Professor Sharpe said.

“If the effects described work through an oestrogen mechanism, they are unlikely to be human relevant because pregnancy levels of oestrogens in humans are far higher than in mice and would swamp any weak oestrogenic effects of bisphenol A,” he said.

BPA, which can interfere with the female sex hormone, is found in small quantities in most people but the levels of exposure are thought by most experts to be too low to result in biological effects. However, some researchers, particularly in the US, have disagreed with this assertion.

Start your day with The Independent, sign up for daily news emails
Arts and Entertainment
musicOfficial chart could be moved to accommodate Friday international release day
Sport
Wes Brown is sent-off
football
News
i100
Sport
Italy celebrate scoring their second try
six nations
Sport
Glenn Murray celebrates scoring against West Ham
footballWest Ham 1 Crystal Palace 3
Arts and Entertainment
Drake continues to tease ahead of the release of his new album
music
ebooks
ebooksA special investigation by Andy McSmith
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Recruitment Genius: Bookkeeper / Office Co-ordinator

£9 per hour: Recruitment Genius: This role is based within a small family run ...

Recruitment Genius: Designer - Print & Digital

£28000 - £32000 per annum: Recruitment Genius: This Design and marketing agenc...

Recruitment Genius: Quantity Surveyor

£46000 per annum: Recruitment Genius: This property investment firm are lookin...

Recruitment Genius: Telesales / Telemarketing Executive - OTE £30k / £35k plus

£18000 - £35000 per annum: Recruitment Genius: This company specialises provid...

Day In a Page

Chelsea vs Tottenham: Harry Kane was at Wembley to see Spurs beat the Blues and win the Capital One Cup - now he's their great hope

Harry Kane interview

The striker was at Wembley to see Spurs beat the Blues and win the Capital One Cup - now he's their great hope
The Last Word: For the good of the game: why on earth don’t we leave Fifa?

Michael Calvin's Last Word

For the good of the game: why on earth don’t we leave Fifa?
HIV pill: Scientists hail discovery of 'game-changer' that cuts the risk of infection among gay men by 86%

Scientists hail daily pill that protects against HIV infection

Breakthrough in battle against global scourge – but will the NHS pay for it?
How we must adjust our lifestyles to nature: Welcome to the 'Anthropocene', the human epoch

Time to play God

Welcome to the 'Anthropocene', the human epoch where we may need to redefine nature itself
MacGyver returns, but with a difference: Handyman hero of classic 1980s TV series to be recast as a woman

MacGyver returns, but with a difference

Handyman hero of classic 1980s TV series to be recast as a woman
Tunnel renaissance: Why cities are hiding roads down in the ground

Tunnel renaissance

Why cities are hiding roads underground
'Backstreet Boys - Show 'Em What You're Made Of': An affectionate look at five middle-aged men

Boys to men

The Backstreet Boys might be middle-aged, married and have dodgy knees, but a heartfelt documentary reveals they’re not going gently into pop’s good night
Crufts 2015: Should foreign dogs be allowed to compete?

Crufts 2015

Should foreign dogs be allowed to compete?
10 best projectors

How to make your home cinema more cinematic: 10 best projectors

Want to recreate the big-screen experience in your sitting room? IndyBest sizes up gadgets to form your film-watching
Manchester City 1 Barcelona 2 player ratings: Luis Suarez? Lionel Messi? Joe Hart? Who was the star man?

Manchester City vs Barcelona player ratings

Luis Suarez? Lionel Messi? Joe Hart? Who was the star man at the Etihad?
Arsenal vs Monaco: Monaco - the making of Gunners' manager Arsene Wenger

Monaco: the making of Wenger

Jack Pitt-Brooke speaks to former players and learns the Frenchman’s man-management has always been one of his best skills
Cricket World Cup 2015: Chris Gayle - the West Indies' enigma lives up to his reputation

Chris Gayle: The West Indies' enigma

Some said the game's eternal rebel was washed up. As ever, he proved he writes the scripts by producing a blistering World Cup innings
In Ukraine a dark world of hybrid warfare and murky loyalties prevails

In Ukraine a dark world of hybrid warfare

This war in the shadows has been going on since the fall of Mr Yanukovych
'Birdman' and 'Bullets Over Broadway': Homage or plagiarism?

Homage or plagiarism?

'Birdman' shares much DNA with Woody Allen's 'Bullets Over Broadway'
Broadchurch ends as damp squib not even David Tennant can revive

A damp squib not even David Tennant can revive

Broadchurch, Series 2 finale, review