Study shows dangers of BPA chemical used in plastic packaging

Bisphenol A is used to line drinks cans and in tests affected the way genes work in the brains of laboratory rats

Further evidence has emerged showing that a chemical used widely in plastic packaging and the lining of drinks cans may be harmful to health.

The latest study has shown that bisphenol A (BPA) can affect the way genes work in the brains of laboratory rats, although other scientists have questioned the relevance of the findings to humans.

Researchers found that feeding BPA to pregnant rats was associated with lasting alterations to the “epigenetic” structure of genes in the brain tissue of their offspring, causing possible changes to certain aspects of sex-specific behaviour, such as chasing, sniffing and aggression.

Previous studies on laboratory animals have also pointed to a possible link between BPA and ill health but this research was criticised by other experts for using very high doses of the chemical, which would not be relevant to levels of human exposure, and to injecting the substance rather than feeding it through the diet, which is how BPA enters the human body.

The latest study by Frances Champagne of Columbia University in New York, published in the Proceeding of the National Academy of Sciences, used what the scientists said were “environmentally relevant” doses of BPA, which were fed to the rats through their diet.

The researchers concluded: “This study provides evidence that low-dose maternal BPA exposure induces long-lasting disruption to epigenetic pathways in the brain of offspring….Importantly, our findings indicate that these BPA-induced changes occur in a sex-specific, brain region-specific and dose-dependent manner.”

Professor Richard Sharpe of the Medical Research Council's Centre for Reproductive Health in Edinburgh said that although the study is well conducted there are still problems that make it difficult to extrapolate the findings to human health.

“Whilst these findings raise the possibility that comparable effects of bisphenol A could occur in humans, several factors suggest this is unlikely. First, the lowest dose used is still 10-20 times higher than normal human bisphenol A exposure,” Professor Sharpe said.

Another problem is that there were large variations in the results beween individual animals, making reproducible results questionable. A third issue was the suggestion that BPA works by interfering with the female hormone oestrogen, as oestrogen levels are much higher in pregnant women than in pregnant mice, Professor Sharpe said.

“If the effects described work through an oestrogen mechanism, they are unlikely to be human relevant because pregnancy levels of oestrogens in humans are far higher than in mice and would swamp any weak oestrogenic effects of bisphenol A,” he said.

BPA, which can interfere with the female sex hormone, is found in small quantities in most people but the levels of exposure are thought by most experts to be too low to result in biological effects. However, some researchers, particularly in the US, have disagreed with this assertion.

Voices
The Sumatran tiger, endemic to the Indonesian island of Sumatra, is an endangered species
voicesJonathon Porritt: The wild tiger population is thought to have dropped by 97 per cent since 1900
News
These photographs released by the University of Maryland Medical Center show images of full face transplant recipient 37-year-old Richard Lee Norris of Hillsville, Virginia
mediaGQ front page features man who underwent full face transplant
Sport
Lionel Messi looks on at the end of the final
football
News
i100
PROMOTED VIDEO
Arts and Entertainment
tv
News
Prince Harry is clearing enjoying the Commonwealth Games judging by this photo
people(a real one this time)
News
Gardai wait for the naked man, who had gone for a skinny dip in Belfast Lough
newsTwo skinny dippers threatened with inclusion on sex offenders’ register as naturists criminalised
News
Your picture is everything in the shallow world of online dating
i100
Life and Style
Attractive women on the Internet: not a myth
techOkCupid boasts about Facebook-style experiments on users
Sport
Van Gaal said that his challenge in taking over Bobby Robson's Barcelona team in 1993 has been easier than the task of resurrecting the current United side
football
News
ebookA unique anthology of reporting and analysis of a crucial period of history
Independent
Travel Shop
the manor
Up to 70% off luxury travel
on city breaks Find out more
santorini
Up to 70% off luxury travel
on chic beach resorts Find out more
sardina foodie
Up to 70% off luxury travel
on country retreats Find out more
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Java Developer

£45000 - £60000 per annum + competitive: Progressive Recruitment: JAVA DEVELO...

HR Business Partner (Maternity Cover 12 Months)

£30000 - £34000 Per Annum 25 days holiday, Private healthcare: Clearwater Peop...

Microsoft Dynamics AX Developer

£475 - £550 per day: Progressive Recruitment: MDAX / Dynamics AX / Microsoft D...

.Net/ C# Developer/ Analyst Programmer - Eciting new Role

£45000 - £50000 per annum + competitive: Progressive Recruitment: .NET/ C# .Pr...

Day In a Page

The children were playing in the street with toy guns. The air strikes were tragically real

The air strikes were tragically real

The children were playing in the street with toy guns
Boozy, ignorant, intolerant, but very polite – The British, as others see us

Britain as others see us

Boozy, ignorant, intolerant, but very polite
Countries that don’t survey their tigers risk losing them altogether

Countries that don’t survey their tigers risk losing them

Jonathon Porritt sounds the alarm
How did our legends really begin?

How did our legends really begin?

Applying the theory of evolution to the world's many mythologies
Watch out: Lambrusco is back on the menu

Lambrusco is back on the menu

Naff Seventies corner-shop staple is this year's Aperol Spritz
A new Russian revolution: Cracks start to appear in Putin’s Kremlin power bloc

A new Russian revolution

Cracks start to appear in Putin’s Kremlin power bloc
Eugene de Kock: Apartheid’s sadistic killer that his country cannot forgive

Apartheid’s sadistic killer that his country cannot forgive

The debate rages in South Africa over whether Eugene de Kock should ever be released from jail
Standing my ground: If sitting is bad for your health, what happens when you stay on your feet for a whole month?

Standing my ground

If sitting is bad for your health, what happens when you stay on your feet for a whole month?
Commonwealth Games 2014: Dai Greene prays for chance to rebuild after injury agony

Greene prays for chance to rebuild after injury agony

Welsh hurdler was World, European and Commonwealth champion, but then the injuries crept in
Israel-Gaza conflict: Secret report helps Israelis to hide facts

Patrick Cockburn: Secret report helps Israel to hide facts

The slickness of Israel's spokesmen is rooted in directions set down by pollster Frank Luntz
The man who dared to go on holiday

The man who dared to go on holiday

New York's mayor has taken a vacation - in a nation that has still to enforce paid leave, it caused quite a stir, reports Rupert Cornwell
Best comedians: How the professionals go about their funny business, from Sarah Millican to Marcus Brigstocke

Best comedians: How the professionals go about their funny business

For all those wanting to know how stand-ups keep standing, here are some of the best moments
The Guest List 2014: Forget the Man Booker longlist, Literary Editor Katy Guest offers her alternative picks

The Guest List 2014

Forget the Man Booker longlist, Literary Editor Katy Guest offers her alternative picks
Jokes on Hollywood: 'With comedy film audiences shrinking, it’s time to move on'

Jokes on Hollywood

With comedy film audiences shrinking, it’s time to move on