The man who can't catch Aids
Discovery may lead to vaccine
Friday 29 March 1996
From these individuals, Dr Paxton and his colleagues have taken the white blood cells, known as CD4 cells, which are the particular target of HIV, cultured the cells in the laboratory, and tried unsuccessfully to infect them with HIV. In the case ofMr C rohn's cells, the researchers could only get the infection to "take" by flooding the cultured cells with huge amounts of virus, far more than would be present in the course of a naturally occurring form of infection. There have been indications that some people might be resistant to HIV infection, because of the chance shuffling of the genes they inherited from their parents. But this evidence is only statistical. The new research has identified specific individuals and their biochemistry to work out the precise mechanism of resistance. Dr Paxton said yesterday, "If we can determine what is protecting these people then you ca n envisage therapy or vaccine design." Dr Paxton and his colleagues have already identified one set of biochemical compounds, known as chemokines, which appear to be acting in these people to defeat HIV. These substances were first recognised only five years ago and appear to play a role in the immune system. They report their findings in the April issue of the scientific journal Nature Medicine. Conventional vaccines consist of antibodies to the infecting agent produced by the immune system. But, partly because HIV subverts the cells of the immune system itself and partly because it is highly variable, no one has succeeded in producing a vaccine against it. The chemokines Dr Paxton and his colleagues have found are not antibodies. They are involved in the "inflammatory" response, when a wound or site of infection becomes inflamed. "I do not believe that next week everybody will be injecting chemokines and curing Aids, but definitely we're on a line," Dr Paxton said. He stressed that any vaccine or treatment was still a long way off: "I'm really worried about how people will take this news - people should not give up a safe sex policy." For Mr Crohn, the thought that his blood might hold a vital secret in the battle against Aids "would be very touching to me." His partner, Jerry Greenwood, died in 1982, before the disease even had a name.
- 1 Germanwings crash: Police make 'significant discovery' at home of co-pilot Andreas Lubitz
- 2 JK Rowling responds to fan tweeting she 'can't see' Dumbledore being gay
- 3 The West has it totally wrong on Lee Kuan Yew
- 4 #FreeTheNipple: Women in Iceland bare breasts in solidarity with trolled student
- 5 Jeremy Clarkson calls on trolls to leave producer Oisin Tymon alone: 'None of this is his fault'
Germanwings crash: Police make 'significant discovery' at home of co-pilot Andreas Lubitz
Andreas Lubitz: Who is Germanwings co-pilot who 'locked out captain and crashed flight 9525'?
#FreeTheNipple: Women in Iceland bare breasts in solidarity with trolled student
Russia unveils plans for high speed railway and superhighway to connect Europe and America
Cate Blanchett loses temper during interview: 'That's your f**king question?'
Nigel Farage brands LGBT activists 'filth' and 'scum' and accuses them of scaring away his children after they invade his local pub
Ukip supporters are 55 or older, white and socially conservative, finds British Social Attitudes Report
JK Rowling responds to fan tweeting she 'can't see' Dumbledore being gay
Russia threatens Denmark with nuclear weapons if it tries to join Nato defence shield
Jeremy Clarkson sacked live: Alan Yentob 'wouldn't rule out' ex Top Gear host's BBC return
Germanwings plane crash live: Andreas Guenter Lubitz intentionally crashed flight 9525 into the Alps in act of mass murder and suicide – latest
£50000 - £65000 per annum: Recruitment Genius: Due to continued business growt...
£20000 - £22000 per annum: Recruitment Genius: An exciting opportunity has ari...
£20000 - £25000 per annum: Recruitment Genius: This is a fantastic opportunity...
£25000 - £30000 per annum: Recruitment Genius: Well established and expanding ...