The man who can't catch Aids

Discovery may lead to vaccine

Scientists have found a man who cannot catch the virus that causes Aids - and his blood may hold the key to developing the first vaccine. In his blood, the New Yorker, Steve Crohn, has the first known substance in the world that will defeat the HIV virus. Scientists already knew of many individuals who remain healthy for a very long time between infection with HIV and developing full blown Aids. The difference in the case of Mr Crohn and the others now identified is that they appear to be resistant to inf ection with HIV in the first place. Mr Crohn, 49, a freelance editor for Fodor's Travel Guides, and another New Yorker who also appears to be immune, were discovered by a young Glaswegian scientist, Dr Bill Paxton, of the Aaron Diamond Aids Research Center in New York. Dr Paxton and his co lleagues have found a further 23 people who, although not completely immune, show some degree of resistance to HIV infection. Many have remained free of HIV despite a history of unsafe sex with multiple sexual partners who subsequently died of Aids.

From these individuals, Dr Paxton and his colleagues have taken the white blood cells, known as CD4 cells, which are the particular target of HIV, cultured the cells in the laboratory, and tried unsuccessfully to infect them with HIV. In the case ofMr C rohn's cells, the researchers could only get the infection to "take" by flooding the cultured cells with huge amounts of virus, far more than would be present in the course of a naturally occurring form of infection. There have been indications that some people might be resistant to HIV infection, because of the chance shuffling of the genes they inherited from their parents. But this evidence is only statistical. The new research has identified specific individuals and their biochemistry to work out the precise mechanism of resistance. Dr Paxton said yesterday, "If we can determine what is protecting these people then you ca n envisage therapy or vaccine design." Dr Paxton and his colleagues have already identified one set of biochemical compounds, known as chemokines, which appear to be acting in these people to defeat HIV. These substances were first recognised only five years ago and appear to play a role in the immune system. They report their findings in the April issue of the scientific journal Nature Medicine. Conventional vaccines consist of antibodies to the infecting agent produced by the immune system. But, partly because HIV subverts the cells of the immune system itself and partly because it is highly variable, no one has succeeded in producing a vaccine against it. The chemokines Dr Paxton and his colleagues have found are not antibodies. They are involved in the "inflammatory" response, when a wound or site of infection becomes inflamed. "I do not believe that next week everybody will be injecting chemokines and curing Aids, but definitely we're on a line," Dr Paxton said. He stressed that any vaccine or treatment was still a long way off: "I'm really worried about how people will take this news - people should not give up a safe sex policy." For Mr Crohn, the thought that his blood might hold a vital secret in the battle against Aids "would be very touching to me." His partner, Jerry Greenwood, died in 1982, before the disease even had a name.

Suggested Topics
PROMOTED VIDEO
Have you tried new the Independent Digital Edition apps?
News
ebooksNow available in paperback
Arts and Entertainment
Babysitter Katie and Paul have terse words in the park
tvReview: The strength of the writing keeps viewers glued to their seats even when they are confronted with the hard-hitting scenes
News
i100
Arts and Entertainment
American singer, acclaimed actor of stage and screen, political activist and civil rights campaigner Paul Robeson (1898 - 1976), rehearses in relaxed mood at the piano.
filmSinger, actor, activist, athlete: Paul Robeson was a cultural giant. But prejudice and intolerance drove him to a miserable death. Now his story is to be told in film...
Sport
England’s opening goalscorer Alex Oxlade-Chamberlain battles with Scotland’s Charlie Mulgrew
FootballEngland must learn to keep possession and dictate games before they are exposed by the likes of Germany and Brazil
Life and Style
Make-up artists prepare contestants for last year’s Miss World, held in Budapest
fashion
Sport
Wigan Athletic’s back-of-the shirt sponsor Premier Range has pulled out due to Malky Mackay’s arrival
Football
Latest stories from i100
Have you tried new the Independent Digital Edition apps?
Independent Dating
and  

By clicking 'Search' you
are agreeing to our
Terms of Use.

iJobs Job Widget
iJobs General

Argyll Scott International: FP&A Manager Supply Chain

Benefits: Argyll Scott International: Argyll Scott is recruiting for a Permane...

Austen Lloyd: Commercial Property NQ+

£30000 - £50000 per annum + EXCELLENT: Austen Lloyd: COMMERCIAL PROPERTY SOLI...

Argyll Scott International: Retail Commercial Finance Analyst

Benefits: Argyll Scott International: Due to further expansion, a leading inte...

Langley James : Senior Technician; Promotion & Training Opp; Borough; upto £32k

£27000 - £32000 per annum + training: Langley James : Senior Technician; Promo...

Day In a Page

US immigration: President Obama ready to press ahead with long-promised plan to overhaul 'broken system' - but will it get past a Republican-controlled Congress?

Immigration: Obama's final frontier

The President is ready to press ahead with the long-promised plan to overhaul America's 'broken system' - but will it get past a Republican-controlled Congress?
Bill Cosby rape allegations explained: Why are these allegations coming out now? Why didn’t these women come forward earlier? And why has nobody taken legal action?

Bill Cosby rape allegations explained

Why are these allegations coming out now? Why has nobody taken legal action? And what happens next for the man once thought of as 'America's Dad'
Four years of excruciating seizures caused by the 1cm tapeworm found burrowing through a man's brain

You know that headache you’ve got?

Four years of excruciating seizures caused by the 1cm tapeworm found burrowing through a man's brain
Travelling to work by scooter is faster than walking and less sweaty than cycling, so why aren’t we all doing it?

Scoot commute

Travelling to work by scooter is faster than walking and less sweaty than cycling, so why aren’t we all doing it?
Paul Robeson: The story of how an American icon was driven to death to be told in film

The Paul Robeson story

How an American icon was driven to death to be told in film
10 best satellite navigation systems

Never get lost again: 10 best satellite navigation systems

Keep your vehicle going in the right direction with a clever device
Paul Scholes column: England must learn to keep possession and dictate games before they are exposed by the likes of Germany and Brazil

Paul Scholes column

England must learn to keep possession and dictate games before they are exposed by the likes of Germany and Brazil
Michael Dawson: I’ll thank Spurs after we win says defender as he prepares to return with Hull

Michael Dawson: I’ll thank Spurs after we win

Hull defender faces his struggling former club on Sunday ready to show what they are missing. But he says he will always be grateful to Tottenham
Frank Warren column: Dr Wu has big plans for the professionals yet he should stick to the amateur game

Frank Warren column

Dr Wu has big plans for the professionals yet he should stick to the amateur game
Synagogue attack: Fear unites both sides of Jerusalem as minister warns restoring quiet could take 'months'

Terror unites Jerusalem after synagogue attack

Rising violence and increased police patrols have left residents of all faiths looking over their shoulders
Medecins sans Frontieres: The Ebola crisis has them in the headlines, but their work goes far beyond West Africa

'How do you carry on? You have to...'

The Ebola crisis has Medecins sans Frontieres in the headlines, but their work goes far beyond West Africa
Isis extends its deadly reach with suicide bombing in Kurdish capital

Isis extends its deadly reach with suicide bombing in Kurdish capital

Residents in what was Iraq’s safest city fear an increase in jihadist attacks, reports Patrick Cockburn
Underwater photography competition winners 2014 - in pictures

'Mysterious and inviting' shot of diver wins photography competition

Stunning image of cenote in Mexico takes top prize
Sir John Major: Negative West End portrayals of politicians put people off voting

Sir John Major hits out at theatres

Negative West End portrayals of politicians put people off voting
Kicking Barbie's butt: How the growth of 3D printing enabled me to make an army of custom-made figurines

Kicking Barbie's butt

How the growth of 3D printing enabled toy-designer to make an army of custom-made figurines