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British troops sent to help combat the Ebola outbreak in West Africa are at increased risk of becoming psychotic or suicidal due to the Ministry of Defence's refusal to stop using mefloquine, the controversial anti-malarial drug.
Lariam (its brand name) is among the anti-malarials being given to the 800 service personnel currently deployed to Sierra Leone on Operation Gritrock.
Fears over the risks of psychosis and suicide prompted the US military to declare it a "drug of last resort" in April 2013, and the US Special Forces Command banned its use more than a year ago. Despite this British soldiers are still being given the drug.
The MoD admitted it continued to prescribe mefloquine as "part of a range of malaria prevention treatments". Officials acknowledge the drug has the potential to cause "side-effects and adverse reactions" and stress the "exact choice of drug" is dependent on factors such as where people are being sent, the health of the individual and their past history.
It is understood that at least one member of the British military in Freetown, Sierra Leone, has suffered "night terrors" and hallucinations after taking mefloquine.
In pictures: Ebola virus Show all 62 1 /62In pictures: Ebola virus In pictures: Ebola virus Ebola virus A health worker from Sierra Leone's Red Cross Society Burial Team 7 carries the corpse of a child in Freetown
In pictures: Ebola virus Ebola virus A health workers from the Sierra Leone's Red Cross Society Burial Team 7 is sprayed with desinfectant after removing a corpse from a house in Freetown
In pictures: Ebola virus Ebola virus Health workers from Sierra Leone's Red Cross Society Burial Team 7 prepare to remove a body from a house in Freetown
AFP
In pictures: Ebola virus Ebola virus Health workers from the Sierra Leone's Red Cross Society Burial Team 7 place a body in a grave at King Tom cemetary in Freetown
In pictures: Ebola virus Ebola virus Mustapha Rogers of the Red Cross talks as health workers from the Sierra Leone's Red Cross Society Burial Team 7 remove a corpse from a house in Freetown
In pictures: Ebola virus Ebola virus A citizen from Mali arrives at a hospital in Murcia city, south-eastern Spain. The protocol for a possible case of Ebola has been activated as the man, who arrived from Mali to Jumilla town in Murcia province five days ago, presents clinical symptoms of high fever and vomiting
EPA
In pictures: Ebola virus Ebola virus Kenyan medical workers show how to handle an infected Ebola patient on a portable negative pressure bed at the Kenyatta national hospital in Nairobi
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In pictures: Ebola virus Ebola virus A health worker sprays disinfectant onto a college in Monrovia, Liberia
AP
In pictures: Ebola virus Ebola virus A burial team in protective gear bury the body of a woman suspected to have died from Ebola virus in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Healthcare workers in protective gear work at an Ebola treatment center in the west of Freetown, Sierra Leone
AP Photo/Michael Duff
In pictures: Ebola virus Ebola virus A healthcare worker in protective gear is sprayed with disinfectant after working in an Ebola treatment center in the west of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A member of the NGO U Fondation leaves a house after visiting quarantined family members suffering from the Ebola virus in Monrovia
In pictures: Ebola virus Ebola virus An Ebola sign placed infront of a home in West Point slum area of Monrovia, Liberia
In pictures: Ebola virus Ebola virus A Liberian man carries his sick brother suspected of having Ebola after being delayed admission to the Island Clinic Ebola Treatment Unit due to a lack of beds at the clinic on the outskirts of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Health workers remove the body a woman who died from the Ebola virus in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A health worker fixes another health worker's protective suit in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus Health workers spray themselves with chlorine disinfectants after removing the body a woman who died of Ebola virus in the Aberdeen district of Freetown, Sierra Leone
In pictures: Ebola virus Ebola virus A woman crawls towards the body of her sister as Ebola burial team members take her sister Mekie Nagbe (28) for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Sophia Doe sits with her grandchildren Beauty Mandi, 9 months (L) and Arthuneh Qunoh, 9, (R), while watching the arrival an Ebola burial team to take away the body of her daughter Mekie Nagbe, 28, for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Varney Jonson (46) grieves as an Ebola burial team takes away the body of his wife Nama Fambule for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus Family members grieve as Ebola burial team members prepare to remove the body of Nama Fambule for cremation in Monrovia, Liberia
In pictures: Ebola virus Ebola virus A Liberian burial squad carry the body of an Ebola victim in Marshall, Margini county, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team dresses in protective clothing before collecting the body of a woman (54) from her home in the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team carries the body of a woman (54) through the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus An Ebola burial team dresses in protective clothing before collecting the body of a woman (54) from her home in the New Kru Town suburb of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Health workers in protective gear carry the body of a woman suspected to have died from Ebola virus, from a house in New Kru Town at the outskirt of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Volunteers in protective suit bury the body of a person who died from Ebola in Waterloo, some 30 kilometers southeast of Freetown
FLORIAN PLAUCHEUR/AFP/Getty Images
In pictures: Ebola virus Ebola virus Nowa Paye (9) is taken to an ambulance after showing signs of the Ebola infection in the village of Freeman Reserve, about 30 miles north of Monrovia, Liberia
In pictures: Ebola virus Ebola virus Medical staff members burn clothes belonging to patients suffering from Ebola, at the French medical NGO Medecins Sans Frontieres (MSF) in Monrovia
PASCAL GUYOT/AFP/Getty Images
In pictures: Ebola virus Ebola virus A medical staff member wearing a protective suit walks past the crematorium where victims of Ebola are burned in Monrovia
In pictures: Ebola virus Ebola virus A Liberian burial team wearing protective clothing loads the body of a 60-year-old Ebola victim after retrieving him from his home
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In pictures: Ebola virus Ebola virus Sick women rest while hoping to enter the new Doctors Without Borders (MSF), Ebola treatment center near Monrovia, Liberia
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In pictures: Ebola virus Ebola virus Hanah Siafa walks in the rain with her children Josephine, 10, and Elija, six, while waiting to enter the new Doctors Without Borders (MSF), Ebola treatment center in Monrovia, Liberia
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In pictures: Ebola virus Ebola virus UNICEF health workers walk through the streets, going house to house to speak about Ebola prevention in New Kru Town, Liberia. The virus has killed more than 1,000 people in four African countries
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In pictures: Ebola virus Ebola virus Local residents watch as public health advocates stage an Ebola awareness and prevention event in Monrovia, Liberia
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In pictures: Ebola virus Ebola virus Public health advocates stage an Ebola awareness and prevention event in Monrovia, Liberia. The Liberian government and international groups are trying to convince residents of the danger and are urging people to wash their hands to help prevent the spread of the epidemic
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In pictures: Ebola virus Ebola virus Hanah Siafa lies with her children Josephine, 10, and Elija, six, while hoping to enter the new Doctors Without Borders (MSF), Ebola treatment center
Getty Images
In pictures: Ebola virus Ebola virus A health worker examines patients for Ebola inside a screening tent, at the Kenema Government Hospital
AP
In pictures: Ebola virus Ebola virus A health worker cleans his hands with chlorinated water before entering an Ebola screening tent at the Kenema Government Hospital, about 86 miles from Sierra Leone’s capital Freetown
AP
In pictures: Ebola virus Ebola virus Aid workers and doctors transfer Miguel Pajares, a Spanish priest who was infected with the Ebola virus while working in Liberia, from a plane to an ambulance as he leaves the Torrejon de Ardoz military airbase, near Madrid, Spain
AP Photo/Spanish Defense Ministry
In pictures: Ebola virus Ebola virus A Liberian money exchanger washes hands between customers as a precaution to prevent infection with the deadly Ebola virus while conducting business in downtown Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A Liberian health worker sprays disinfectant on a drivers boots to stop the spread of the deadly Ebola virus at the Christian charity Samaritan Purse head offices in Monrovia, Liberia. Over 660 people have died of Ebola in West Africa in 2014 making it the world's deadliest outbreak to date according to statistics from the World Health Organisation
EPA
In pictures: Ebola virus Ebola virus A Liberian taxi driver wears protective gloves as a precaution to prevent infection with the deadly Ebola virus whilst driving in downtown Monrovia, Liberia. Many Liberians have taken to wearing gloves and washing hands after every interaction in an attempt to curb the spread of the deadly virus
EPA
In pictures: Ebola virus Ebola virus A Liberian money exchanger wears protective gloves as a precaution to prevent infection with the deadly Ebola virus while transacting business with customers in downtown Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A woman from Liberia takes food to a sick relative in the Ebola isolation unit at the ELWA Hospital where US doctor Kent Bradley is being quarantined having contracted the Ebola virus. Over 660 people have died of Ebola in West Africa in 2014 making it the world's deadliest outbreak to date according to statistics from the World Health Organisation
EPA
In pictures: Ebola virus Ebola virus The disease has now spread to Liberia and, for the first time, Sierra Leone and Nigeria, killing at least 672 people in 1,201 cases, according to the World Health Organisation’s latest figures
AP
In pictures: Ebola virus Ebola virus Health specialists prepare for work in an isolation ward for patients at the Medecins Sans Frontieres facility in southern Guinea
AFP/Getty Images
In pictures: Ebola virus Ebola virus A Liberian street vendor wears protective gloves as a precaution to prevent infection with the deadly Ebola virus while transacting business with customers in downtown Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A nurse from Liberia sprays preventives to disinfect the waiting area for visitors at the ELWA Hospital where a US doctor Kent Bradley is being quarantined in the hospitals isolation unit having contracted the Ebola virus, Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus Staff of the 'Doctors without Borders' ('Medecin sans frontieres') medical aid organisation carry the body of a person killed by the virus
In pictures: Ebola virus Ebola virus A Liberia man (right) talks to a nurse (left) about the health of his relative who is in the isolation unit of the ELWA Hospital where a US doctor Kent Bradley is being quarantined having contracted the Ebola virus, Monrovia, Liberia
EPA
In pictures: Ebola virus Ebola virus A nurse from Liberia walks to spray preventives to disinfect the waiting area for visitors at the ELWA Hospital where a US doctor Kent Bradley is being quarantined in the hospitals isolation unit having contracted the Ebola virus
EPA
In pictures: Ebola virus Ebola virus Staff of the Christian charity Samaritan's Purse put on protective gear in the ELWA hospital in the Liberian capital Monrovia
AFP
In pictures: Ebola virus Ebola virus Lagos State Health Commissioner Jide Idris, speaks, during a news conference in Lagos, Nigeria. No one knows for sure just how many people Patrick Sawyer came into contact with the day he boarded a flight in Liberia, had a stopover in Ghana, changed planes in Togo, and then arrived in Nigeria, where authorities say he died days later from Ebola
AP Photo/Sunday Alamba
In pictures: Ebola virus Ebola virus Staff of the Christian charity Samaritan's Purse put on protective gear in the ELWA hospital in the Liberian capital Monrovia. An American doctor battling West Africa's Ebola epidemic has himself fallen sick with the disease in Liberia, Samaritan's Purse said
AP
In pictures: Ebola virus Ebola virus Protective gear including boots, gloves, masks and suits, drying after being used in a treatment room in the ELWA hospital in the Liberian capital Monrovia
AFP
In pictures: Ebola virus Ebola virus A Liberian man holding a Civet being sold on a roadside as bush meat in Lofa County. Bush meat is one of the major carriers of the Ebola virus. The Liberian government and International partners have warned people to not eat it. The World Health Organisation (WHO) reported that a total of 888 Ebola cases including 539 deaths have been recorded in West Africa since February
AFP
In pictures: Ebola virus Ebola virus People unload protection and healthcare material at Conakry's airport, to help fight the spread of the Ebola virus and treat people who have been already infected
AFP/Getty Images
In pictures: Ebola virus Ebola virus Body of evidence: health workers transport a casket of a nun whose death resulted from an Ebola infection in Zaire in 1995
Getty
In pictures: Ebola virus Ebola virus Peter Piot in Yambuku, northern Congo (then Zaire), in 1976, where he was part of the original team to discover the Ebola virus
J Breman
In pictures: Ebola virus Ebola virus A member of Doctors Without Borders helps to unload protection and healthcare materials in Guinea
Getty
In pictures: Ebola virus Ebola virus Doctors in protective gear work inside the Medecins Sans Frontieres isolation ward as Guinea faced the worst ever outbreak of the Ebola virus
Getty Images
The dangers of the drug were revealed by The Independent more than a year ago. Last night senior politicians and military figures criticised the MoD for continuing to use it. Major General Patrick Cordingley, commander of the Desert Rats in the first Gulf War, said: "I'm appalled to hear the MoD is still allowing it to be prescribed. I have personally suffered the consequences of taking it and in my case it was extremely unpleasant – hallucinating and feeling really quite suicidal for several days. I found it very frightening."
The MoD's decision to continue using the drug "beggars belief" said MP Madeleine Moon, a member of the Commons Defence Select Committee. "Our personnel are on a high-risk mission … they should not be given medication that comes with a known risk of hallucinations."
Lieutenant Colonel Ashley Croft, who has served in the Royal Army Medical Corps for 25 years and is an expert on malaria, said: "I can't see why anybody would be offered mefloquine or why they would even ask for it." He added: "It shouldn't be part of the routine list of drugs that are given to people carrying out responsible and dangerous tasks."
The risk of "neuropsychiatric side-effects" is well-established, according to the Medicines and Healthcare Products Regulatory Agency, which has received more than 2,200 reports of "adverse reactions" to the drug since 1986.
In a letter to doctors in October last year, Roche, makers of Lariam, warned that "hallucinations, psychosis, suicide, suicidal thoughts and self-endangering behaviour have been reported".
An MoD spokesperson said: "Our medical advice is based on the guidelines set out by Public Health England … The MoD continues to prescribe mefloquine as part of the range of malaria prevention treatments."
Mefloquine is not being given to medical staff sent out by Public Health England.
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