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US President adds that the substance is actually less damaging ‘in terms of its impact on the individual customer’

GSK sets aside £2.2bn to cover Avandia claims

Legal bills related to diabetes drug will wipe out profits for the past quarter

Colorado Rapids win MLS

The Colorado Rapids were crowned champions of Major League Soccer for the first time after a 2-1 extra-time win over FC Dallas on Sunday.

Fear and loathing in the nastiest campaign ever

From Barack Obama as the Angel of Death to accusations of Tea Party witchcraft – the midterm election propaganda battle has stooped to new lows

Leading article: Time, please!

Researchers from the US National Institute of Standards and Technology in Boulder, Colorado, have demonstrated, using two phenomenally precise atomic clocks, that the passage of time really does change depending on where you are. One of the clocks was placed just one foot above the other and, thanks to the lesser gravitational pull of the earth exerted on the latter, showed that less time had elapsed when they examined it. Comforting to know that Einstein's theory of relativity is actually correct. It would have been terribly inconvenient, not least for the physics community, to have had to reopen that old question.

Charlie Sheen sentenced for attacking wife

Actor Charlie Sheen was sentenced today after pleading guilty to attacking his wife in a Christmas Day argument in exchange for the withdrawal of more serious charges.

American craft ales: Brewed in the USA

A new generation of American craft ales will take centre stage at next week's Great British Beer Festival. Will Hawkes asks, what's the secret of their success?

Anadarko looks at onshore oil

Anadarko Petroleum, the Texan partner in BP's Deepwater Horizon oil well which exploded in April, is eyeing a 75 per cent stake in the onshore Jolly Ranch scheme in Colorado.

Rocky season in the sun: Vail also offers a range of summer activities

"Present it to him. Set the hook. Pull your rod up to 12 o'clock. Now, snag him, snag him!" There follows about 10 seconds of giggles from my ponytailed fly-fishing instructor, Ryan Schmidt, who up until this point has been the epitome of laid-back fisherman cool, standing waist-deep several yards away from me downstream. But not now. Ryan has transformed into an excited child as the large rainbow trout he's had his eye on for the past half-hour has decided to gobble my fly and disappear to the depths of Eagle Creek.

Obama commits nearly $2 billion to solar companies

President Barack Obama, under pressure to spur job growth, said today that two solar energy companies will get nearly $2 billion in US loan guarantees to create as many as 5,000 green jobs.

URS wins takeover battle for Scott Wilson

URS last night won the takeover battle for the engineering consultancy Scott Wilson, raising its bid to 290p a share, which adds up to the second biggest premium paid for a UK company in the last decade.

Read our lips: no new taxes (and to hell with the results)

Money's so tight in Colorado Springs that the street lights are dark and the police have had to sell their helicopters on eBay. Yet residents are ecstatic. David Usborne on a small attack on big government

Colorado students fight for gun rights

University's bid to prevent Virginia-style rampage is stalled by campus opposition

To the wild frontiers: America's backwoods ski resorts offer new challenges

Forget the flat, icy slopes of Killington in Vermont, or the speed traps and over-eager ski patrols of Vail in Colorado: the real beating heart of the US ski industry has always been the powder-laden, character-filled and downright scary resorts that cling to America's steeper mountains. Some of these towns have histories stretching back to the gold-rush days, others are authentic cowboy hang-outs where Stetson hats outnumber beanies. Yet more are mining settlements that happen to back on to incredible slopes. All share the small-town Americana culture that Springsteen sings about, and tend to be as wild and carefree as their bearded patrons.

Katie Jarvis - Essex's accidental actress

Katie Jarvis followed the critical acclaim of Fish Tank with awards, more film offers and a baby daughter. She tells Charlotte Cripps that she finds her life increasingly surreal for a teenager
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Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
3.	Provence 6 nights B&B by train from £599pp
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No postcode? No vote

Floating voters

How living on a houseboat meant I didn't officially 'exist'
Louis Theroux's affable Englishman routine begins to wear thin

By Reason of Insanity

Louis Theroux's affable Englishman routine begins to wear thin
Power dressing is back – but no shoulderpads!

Power dressing is back

But banish all thoughts of Eighties shoulderpads
Spanish stone-age cave paintings 'under threat' after being re-opened to the public

Spanish stone-age cave paintings in Altamira 'under threat'

Caves were re-opened to the public
'I was the bookies’ favourite to be first to leave the Cabinet'

Vince Cable interview

'I was the bookies’ favourite to be first to leave the Cabinet'
Election 2015: How many of the Government's coalition agreement promises have been kept?

Promises, promises

But how many coalition agreement pledges have been kept?
The Gaza fisherman who built his own reef - and was shot dead there by an Israeli gunboat

The death of a Gaza fisherman

He built his own reef, and was fatally shot there by an Israeli gunboat
Saudi Arabia's airstrikes in Yemen are fuelling the Gulf's fire

Saudi airstrikes are fuelling the Gulf's fire

Arab intervention in Yemen risks entrenching Sunni-Shia divide and handing a victory to Isis, says Patrick Cockburn
Zayn Malik's departure from One Direction shows the perils of fame in the age of social media

The only direction Zayn could go

We wince at the anguish of One Direction's fans, but Malik's departure shows the perils of fame in the age of social media
Young Magician of the Year 2015: Meet the schoolgirl from Newcastle who has her heart set on being the competition's first female winner

Spells like teen spirit

A 16-year-old from Newcastle has set her heart on being the first female to win Young Magician of the Year. Jonathan Owen meets her
Jonathan Anderson: If fashion is a cycle, this young man knows just how to ride it

If fashion is a cycle, this young man knows just how to ride it

British designer Jonathan Anderson is putting his stamp on venerable house Loewe
Number plates scheme could provide a licence to offend in the land of the free

Licence to offend in the land of the free

Cash-strapped states have hit on a way of making money out of drivers that may be in collision with the First Amendment, says Rupert Cornwell
From farm to fork: Meet the Cornish fishermen, vegetable-growers and butchers causing a stir in London's top restaurants

From farm to fork in Cornwall

One man is bringing together Cornwall's most accomplished growers, fishermen and butchers with London's best chefs to put the finest, freshest produce on the plates of some of the country’s best restaurants
Robert Parker interview: The world's top wine critic on tasting 10,000 bottles a year, absurd drinking notes and New World wannabes

Robert Parker interview

The world's top wine critic on tasting 10,000 bottles a year, absurd drinking notes and New World wannabes
Don't believe the stereotype - or should you?

Don't believe the stereotype - or should you?

We exaggerate regional traits and turn them into jokes - and those on the receiving end are in on it too, says DJ Taylor