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US President adds that the substance is actually less damaging ‘in terms of its impact on the individual customer’

GSK sets aside £2.2bn to cover Avandia claims

Legal bills related to diabetes drug will wipe out profits for the past quarter

Colorado Rapids win MLS

The Colorado Rapids were crowned champions of Major League Soccer for the first time after a 2-1 extra-time win over FC Dallas on Sunday.

Fear and loathing in the nastiest campaign ever

From Barack Obama as the Angel of Death to accusations of Tea Party witchcraft – the midterm election propaganda battle has stooped to new lows

Leading article: Time, please!

Researchers from the US National Institute of Standards and Technology in Boulder, Colorado, have demonstrated, using two phenomenally precise atomic clocks, that the passage of time really does change depending on where you are. One of the clocks was placed just one foot above the other and, thanks to the lesser gravitational pull of the earth exerted on the latter, showed that less time had elapsed when they examined it. Comforting to know that Einstein's theory of relativity is actually correct. It would have been terribly inconvenient, not least for the physics community, to have had to reopen that old question.

Charlie Sheen sentenced for attacking wife

Actor Charlie Sheen was sentenced today after pleading guilty to attacking his wife in a Christmas Day argument in exchange for the withdrawal of more serious charges.

American craft ales: Brewed in the USA

A new generation of American craft ales will take centre stage at next week's Great British Beer Festival. Will Hawkes asks, what's the secret of their success?

Anadarko looks at onshore oil

Anadarko Petroleum, the Texan partner in BP's Deepwater Horizon oil well which exploded in April, is eyeing a 75 per cent stake in the onshore Jolly Ranch scheme in Colorado.

Rocky season in the sun: Vail also offers a range of summer activities

"Present it to him. Set the hook. Pull your rod up to 12 o'clock. Now, snag him, snag him!" There follows about 10 seconds of giggles from my ponytailed fly-fishing instructor, Ryan Schmidt, who up until this point has been the epitome of laid-back fisherman cool, standing waist-deep several yards away from me downstream. But not now. Ryan has transformed into an excited child as the large rainbow trout he's had his eye on for the past half-hour has decided to gobble my fly and disappear to the depths of Eagle Creek.

Obama commits nearly $2 billion to solar companies

President Barack Obama, under pressure to spur job growth, said today that two solar energy companies will get nearly $2 billion in US loan guarantees to create as many as 5,000 green jobs.

URS wins takeover battle for Scott Wilson

URS last night won the takeover battle for the engineering consultancy Scott Wilson, raising its bid to 290p a share, which adds up to the second biggest premium paid for a UK company in the last decade.

Read our lips: no new taxes (and to hell with the results)

Money's so tight in Colorado Springs that the street lights are dark and the police have had to sell their helicopters on eBay. Yet residents are ecstatic. David Usborne on a small attack on big government

Colorado students fight for gun rights

University's bid to prevent Virginia-style rampage is stalled by campus opposition

To the wild frontiers: America's backwoods ski resorts offer new challenges

Forget the flat, icy slopes of Killington in Vermont, or the speed traps and over-eager ski patrols of Vail in Colorado: the real beating heart of the US ski industry has always been the powder-laden, character-filled and downright scary resorts that cling to America's steeper mountains. Some of these towns have histories stretching back to the gold-rush days, others are authentic cowboy hang-outs where Stetson hats outnumber beanies. Yet more are mining settlements that happen to back on to incredible slopes. All share the small-town Americana culture that Springsteen sings about, and tend to be as wild and carefree as their bearded patrons.

Katie Jarvis - Essex's accidental actress

Katie Jarvis followed the critical acclaim of Fish Tank with awards, more film offers and a baby daughter. She tells Charlotte Cripps that she finds her life increasingly surreal for a teenager
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Independent Travel
Pompeii, Capri & the Bay of Naples
Seven Cities of Italy
Burgundy, the River Rhone & Provence
Prague, Budapest and Vienna
Lake Garda
Minoan Crete and Santorini
Prices correct as of 15 May 2015
The Greek referendum exposes a gaping hole at the heart of the European Union – its distinct lack of any genuine popular legitimacy

Gaping hole at the heart of the European Union

Treatment of Greece has shown up a lack of genuine legitimacy
Number of young homeless in Britain 'more than three times the official figures'

'Everything changed when I went to the hostel'

Number of young homeless people in Britain is 'more than three times the official figures'
Compton Cricket Club

Compton Cricket Club

Portraits of LA cricketers from notorious suburb to be displayed in London
London now the global money-laundering centre for the drug trade, says crime expert

Wlecome to London, drug money-laundering centre for the world

'Mexico is its heart and London is its head'
The Buddhist temple minutes from Centre Court that helps a winner keep on winning

The Buddhist temple minutes from Centre Court

It helps a winner keep on winning
Is this the future of flying: battery-powered planes made of plastic, and without flight decks?

Is this the future of flying?

Battery-powered planes made of plastic, and without flight decks
Isis are barbarians – but the Caliphate is a dream at the heart of all Muslim traditions

Isis are barbarians

but the Caliphate is an ancient Muslim ideal
The Brink's-Mat curse strikes again: three tons of stolen gold that brought only grief

Curse of Brink's Mat strikes again

Death of John 'Goldfinger' Palmer the latest killing related to 1983 heist
Greece debt crisis: 'The ministers talk to us about miracles' – why Greeks are cynical ahead of the bailout referendum

'The ministers talk to us about miracles'

Why Greeks are cynical ahead of the bailout referendum
Call of the wild: How science is learning to decode the way animals communicate

Call of the wild

How science is learning to decode the way animals communicate
Greece debt crisis: What happened to democracy when it’s a case of 'Vote Yes or else'?

'The economic collapse has happened. What is at risk now is democracy...'

If it doesn’t work in Europe, how is it supposed to work in India or the Middle East, asks Robert Fisk
The science of swearing: What lies behind the use of four-letter words?

The science of swearing

What lies behind the use of four-letter words?
The Real Stories of Migrant Britain: Clive fled from Zimbabwe - now it won't have him back

The Real Stories of Migrant Britain

Clive fled from Zimbabwe - now it won’t have him back
Africa on the menu: Three foodie friends want to popularise dishes from the continent

Africa on the menu

Three foodie friends want to popularise dishes from the hot new continent
Donna Karan is stepping down after 30 years - so who will fill the DKNY creator's boots?

Who will fill Donna Karan's boots?

The designer is stepping down as Chief Designer of DKNY after 30 years. Alexander Fury looks back at the career of 'America's Chanel'