Partygoers smoke marijuana during a Prohibition-era themed New Year's Eve party celebrating the start of retail pot sales in Denver

A pot of gold? Colorado's pilot scheme to legalise recreational marijuana could raise millions in tax dollars...

... and mark the beginning of a sea-change in attitudes around the globe

A man takes part in a collective cannabis smoking event in Denver, Colorado. Colorado will become the first state to allow the sale of marijuana for recreational use in shops from 1 January 2014

Green Wednesday: Colorado prepares for over the counter sale of recreational marijuana

Colorado will become the first state in the US to allow the sale of marijuana for recreational use in shops from New Year's Day

Police warning over 'Speckled Rolex' ecstasy pills after one man dies

The ecstasy-like yellow pills have been linked to the death of one and hospitalisation of four others in Northern Ireland

Film review: How to Make Money Selling Drugs makes some compelling arguments for legalisation

Documentaries about America’s “war on drugs” tend to be grim and earnest affairs.

Withdrawn arthritis drug Vioxx. It is hoped that genetic discoveries might lead to discover new medicines for this and other complex diseases

'Faulty' DNA discovery could point to cure for arthritis

Scientists have identified DNA associated with an increased risk of rheumatoid arthritis, holding out hope of a new treatment or even a cure.

Rebollo in 1996, when he attended a Mexican/US anti-drugs summit in Mexico City

General Jesus Gutierrez Rebollo: Mexican general who became a drugs czar but who was convicted of aiding a powerful narcotics cartel

Jesus Gutierrez Rebollo was a Mexican general who became a drug czar whose career ended in disgrace thanks to his arrest and conviction for aiding a powerful drug cartel. The general, one of the highest-level officials to have been convicted of drug-trafficking in Mexico, was hailed as a seasoned general of “impeccable integrity”.

Two inmates have been arrested on suspicion of murder after a prisoner was found dead at HMP Lindholme

Two inmates arrested after death of prisoner in Lindholme prison

A snap inspection in the summer was highly critical of the jail's wing for low-risk prisoners

Nigella Lawson, arrives at Isleworth Crown Court

Nigella Lawson evidence: Scotland Yard review shows this is a test of police’s attitude to celebrity drug use

Scotland Yard had initially said it would not take action but would review the decision if new evidence came to light

Nigella Lawson, arrives at Isleworth Crown Court in London

Nigella Lawson case: How come celebs aren't stopped and searched?

Yesterday morning we were told that Nigella Lawson is not to be investigated for cocaine use. During the trial of her two former aides she had admitted taking the drug, but the police have said she will not be investigated "at this stage". Well there's a thing.

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

When Newsnight became Brass Eye: Jeremy Paxman claims internet used to facilitate masturbation ‘or worse’

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

A mosquito waiting to be studied - scientists have identified the changes to the genes of the malaria parasite that make it resistant to one of the last effective drugs

Scientists identify resistance gene in malaria parasite

Discovery of genes that confer resistance to the drug artemisinin is major step forward for treatment of the disease

Melissa Reid, right, and Michaella McCollum arrive for their court hearing in Lima

Six years in a Peruvian jail for British women found with £1.5m of cocaine

Guilty pair Melissa Reid and Michaella McCollum could apply to serve their sentences here

GlaxoSmithKline

GlaxoSmithKline to stop paying doctors to promote its drugs

British pharmaceutical giant GlaxoSmithKline (GSK) has announced that it will stop paying doctors to promote its products, in a first for a major drugs company.

Matthew Perry sparks furious drug debate with Peter Hitchens on Newsnight

The pair formed part of a discussion on specialist drugs courts, in which former addicts will sit as lay magistrates

British national Andrea Waldeck reads a bible as she sits in a courtroom in Surabaya, Indonesia

Former police community support officer Andrea Waldeck faces 16 years in Indonesian prison for drug-smuggling

A former Gloucestershire police community support officer who admitted drug-smuggling is facing 16 years in an Indonesian prison, if judges agree to prosecution demands.

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Mystery of the Ground Zero wedding photo

A shot in the dark

Mystery of the wedding photo from Ground Zero
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His life, the universe and everything

New biography sheds light on comic genius of Douglas Adams
Save us from small screen superheroes

Save us from small screen superheroes

Shows like Agents of S.H.I.E.L.D are little more than marketing tools
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Reach for the skies

From pools to football pitches, rooftop living is looking up
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Some hotels go all out on facilities; others stand out for the sheer quality of treatments
These Iranian-controlled Shia militias used to specialise in killing American soldiers. Now they are fighting Isis, backed up by US airstrikes

Widespread fear of Isis is producing strange bedfellows

Iranian-controlled Shia militias that used to kill American soldiers are now fighting Isis, helped by US airstrikes
Topshop goes part Athena poster, part last spring Prada

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Shoppers don't come to Topshop for the unique
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Toy breaks out of the nursery and heads for the gallery
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Urbanites are cursed with an acronym pointing to Employed but No Disposable Income or Savings
Paisley’s decision to make peace with IRA enemies might remind the Arabs of Sadat

Ian Paisley’s decision to make peace with his IRA enemies

His Save Ulster from Sodomy campaign would surely have been supported by many a Sunni imam
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'She was a singer, a superstar, an addict, but to me, her mother, she is simply Amy'

Exclusive extract from Janis Winehouse's poignant new memoir
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Is this the role to win Cumberbatch an Oscar?

The Imitation Game, film review
England and Roy Hodgson take a joint step towards redemption in Basel

England and Hodgson take a joint step towards redemption

Welbeck double puts England on the road to Euro 2016
Relatives fight over Vivian Maier’s rare photos

Relatives fight over Vivian Maier’s rare photos

Pictures removed from public view as courts decide ownership
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Donatella Versace at New York Fashion Week