Partygoers smoke marijuana during a Prohibition-era themed New Year's Eve party celebrating the start of retail pot sales in Denver

A pot of gold? Colorado's pilot scheme to legalise recreational marijuana could raise millions in tax dollars...

... and mark the beginning of a sea-change in attitudes around the globe

A man takes part in a collective cannabis smoking event in Denver, Colorado. Colorado will become the first state to allow the sale of marijuana for recreational use in shops from 1 January 2014

Green Wednesday: Colorado prepares for over the counter sale of recreational marijuana

Colorado will become the first state in the US to allow the sale of marijuana for recreational use in shops from New Year's Day

Police warning over 'Speckled Rolex' ecstasy pills after one man dies

The ecstasy-like yellow pills have been linked to the death of one and hospitalisation of four others in Northern Ireland

Film review: How to Make Money Selling Drugs makes some compelling arguments for legalisation

Documentaries about America’s “war on drugs” tend to be grim and earnest affairs.

Withdrawn arthritis drug Vioxx. It is hoped that genetic discoveries might lead to discover new medicines for this and other complex diseases

'Faulty' DNA discovery could point to cure for arthritis

Scientists have identified DNA associated with an increased risk of rheumatoid arthritis, holding out hope of a new treatment or even a cure.

Rebollo in 1996, when he attended a Mexican/US anti-drugs summit in Mexico City

General Jesus Gutierrez Rebollo: Mexican general who became a drugs czar but who was convicted of aiding a powerful narcotics cartel

Jesus Gutierrez Rebollo was a Mexican general who became a drug czar whose career ended in disgrace thanks to his arrest and conviction for aiding a powerful drug cartel. The general, one of the highest-level officials to have been convicted of drug-trafficking in Mexico, was hailed as a seasoned general of “impeccable integrity”.

Two inmates have been arrested on suspicion of murder after a prisoner was found dead at HMP Lindholme

Two inmates arrested after death of prisoner in Lindholme prison

A snap inspection in the summer was highly critical of the jail's wing for low-risk prisoners

Nigella Lawson, arrives at Isleworth Crown Court

Nigella Lawson evidence: Scotland Yard review shows this is a test of police’s attitude to celebrity drug use

Scotland Yard had initially said it would not take action but would review the decision if new evidence came to light

Nigella Lawson, arrives at Isleworth Crown Court in London

Nigella Lawson case: How come celebs aren't stopped and searched?

Yesterday morning we were told that Nigella Lawson is not to be investigated for cocaine use. During the trial of her two former aides she had admitted taking the drug, but the police have said she will not be investigated "at this stage". Well there's a thing.

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

When Newsnight became Brass Eye: Jeremy Paxman claims internet used to facilitate masturbation ‘or worse’

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

A mosquito waiting to be studied - scientists have identified the changes to the genes of the malaria parasite that make it resistant to one of the last effective drugs

Scientists identify resistance gene in malaria parasite

Discovery of genes that confer resistance to the drug artemisinin is major step forward for treatment of the disease

Melissa Reid, right, and Michaella McCollum arrive for their court hearing in Lima

Six years in a Peruvian jail for British women found with £1.5m of cocaine

Guilty pair Melissa Reid and Michaella McCollum could apply to serve their sentences here

GlaxoSmithKline

GlaxoSmithKline to stop paying doctors to promote its drugs

British pharmaceutical giant GlaxoSmithKline (GSK) has announced that it will stop paying doctors to promote its products, in a first for a major drugs company.

Matthew Perry sparks furious drug debate with Peter Hitchens on Newsnight

The pair formed part of a discussion on specialist drugs courts, in which former addicts will sit as lay magistrates

British national Andrea Waldeck reads a bible as she sits in a courtroom in Surabaya, Indonesia

Former police community support officer Andrea Waldeck faces 16 years in Indonesian prison for drug-smuggling

A former Gloucestershire police community support officer who admitted drug-smuggling is facing 16 years in an Indonesian prison, if judges agree to prosecution demands.

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Burgundy, the River Rhone & Provence – MS Swiss Corona - seven nights from £999pp
Lake Maggiore, Orta and the Matterhorn – seven nights from £899pp
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Noel Fielding's 'Luxury Comedy': A land of the outright bizarre

Noel Fielding's 'Luxury Comedy'

A land of the outright bizarre
What are the worst 'Word Crimes'?

What are the worst 'Word Crimes'?

‘Weird Al’ Yankovic's latest video is an ode to good grammar. But what do The Independent’s experts think he’s missed out?
Can Secret Cinema sell 80,000 'Back to the Future' tickets?

The worst kept secret in cinema

A cult movie event aims to immerse audiences of 80,000 in ‘Back to the Future’. But has it lost its magic?
Facebook: The new hatched, matched and dispatched

The new hatched, matched and dispatched

Family events used to be marked in the personal columns. But now Facebook has usurped the ‘Births, Deaths and Marriages’ announcements
Why do we have blood types?

Are you my type?

All of us have one but probably never wondered why. Yet even now, a century after blood types were discovered, it’s a matter of debate what they’re for
Honesty box hotels: You decide how much you pay

Honesty box hotels

Five hotels in Paris now allow guests to pay only what they think their stay was worth. It seems fraught with financial risk, but the honesty policy has its benefit
Commonwealth Games 2014: Why weight of pressure rests easy on Michael Jamieson’s shoulders

Michael Jamieson: Why weight of pressure rests easy on his shoulders

The Scottish swimmer is ready for ‘the biggest race of my life’ at the Commonwealth Games
Some are reformed drug addicts. Some are single mums. All are on benefits. But now these so-called 'scroungers’ are fighting back

The 'scroungers’ fight back

The welfare claimants battling to alter stereotypes
Amazing video shows Nasa 'flame extinguishment experiment' in action

Fireballs in space

Amazing video shows Nasa's 'flame extinguishment experiment' in action
A Bible for billionaires

A Bible for billionaires

Find out why America's richest men are reading John Brookes
Paranoid parenting is on the rise - and our children are suffering because of it

Paranoid parenting is on the rise

And our children are suffering because of it
For sale: Island where the Magna Carta was sealed

Magna Carta Island goes on sale

Yours for a cool £4m
Phone hacking scandal special report: The slide into crime at the 'News of the World'

The hacker's tale: the slide into crime at the 'News of the World'

Glenn Mulcaire was jailed for six months for intercepting phone messages. James Hanning tells his story in a new book. This is an extract
We flinch, but there are degrees of paedophilia

We flinch, but there are degrees of paedophilia

Child abusers are not all the same, yet the idea of treating them differently in relation to the severity of their crimes has somehow become controversial
The truth about conspiracy theories is that some require considering

The truth about conspiracy theories is that some require considering

For instance, did Isis kill the Israeli teenagers to trigger a war, asks Patrick Cockburn