Partygoers smoke marijuana during a Prohibition-era themed New Year's Eve party celebrating the start of retail pot sales in Denver

A pot of gold? Colorado's pilot scheme to legalise recreational marijuana could raise millions in tax dollars...

... and mark the beginning of a sea-change in attitudes around the globe

A man takes part in a collective cannabis smoking event in Denver, Colorado. Colorado will become the first state to allow the sale of marijuana for recreational use in shops from 1 January 2014

Green Wednesday: Colorado prepares for over the counter sale of recreational marijuana

Colorado will become the first state in the US to allow the sale of marijuana for recreational use in shops from New Year's Day

Police warning over 'Speckled Rolex' ecstasy pills after one man dies

The ecstasy-like yellow pills have been linked to the death of one and hospitalisation of four others in Northern Ireland

Film review: How to Make Money Selling Drugs makes some compelling arguments for legalisation

Documentaries about America’s “war on drugs” tend to be grim and earnest affairs.

Withdrawn arthritis drug Vioxx. It is hoped that genetic discoveries might lead to discover new medicines for this and other complex diseases

'Faulty' DNA discovery could point to cure for arthritis

Scientists have identified DNA associated with an increased risk of rheumatoid arthritis, holding out hope of a new treatment or even a cure.

Rebollo in 1996, when he attended a Mexican/US anti-drugs summit in Mexico City

General Jesus Gutierrez Rebollo: Mexican general who became a drugs czar but who was convicted of aiding a powerful narcotics cartel

Jesus Gutierrez Rebollo was a Mexican general who became a drug czar whose career ended in disgrace thanks to his arrest and conviction for aiding a powerful drug cartel. The general, one of the highest-level officials to have been convicted of drug-trafficking in Mexico, was hailed as a seasoned general of “impeccable integrity”.

Two inmates have been arrested on suspicion of murder after a prisoner was found dead at HMP Lindholme

Two inmates arrested after death of prisoner in Lindholme prison

A snap inspection in the summer was highly critical of the jail's wing for low-risk prisoners

Nigella Lawson, arrives at Isleworth Crown Court

Nigella Lawson evidence: Scotland Yard review shows this is a test of police’s attitude to celebrity drug use

Scotland Yard had initially said it would not take action but would review the decision if new evidence came to light

Nigella Lawson, arrives at Isleworth Crown Court in London

Nigella Lawson case: How come celebs aren't stopped and searched?

Yesterday morning we were told that Nigella Lawson is not to be investigated for cocaine use. During the trial of her two former aides she had admitted taking the drug, but the police have said she will not be investigated "at this stage". Well there's a thing.

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

When Newsnight became Brass Eye: Jeremy Paxman claims internet used to facilitate masturbation ‘or worse’

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

A mosquito waiting to be studied - scientists have identified the changes to the genes of the malaria parasite that make it resistant to one of the last effective drugs

Scientists identify resistance gene in malaria parasite

Discovery of genes that confer resistance to the drug artemisinin is major step forward for treatment of the disease

Melissa Reid, right, and Michaella McCollum arrive for their court hearing in Lima

Six years in a Peruvian jail for British women found with £1.5m of cocaine

Guilty pair Melissa Reid and Michaella McCollum could apply to serve their sentences here

GlaxoSmithKline

GlaxoSmithKline to stop paying doctors to promote its drugs

British pharmaceutical giant GlaxoSmithKline (GSK) has announced that it will stop paying doctors to promote its products, in a first for a major drugs company.

Matthew Perry sparks furious drug debate with Peter Hitchens on Newsnight

The pair formed part of a discussion on specialist drugs courts, in which former addicts will sit as lay magistrates

British national Andrea Waldeck reads a bible as she sits in a courtroom in Surabaya, Indonesia

Former police community support officer Andrea Waldeck faces 16 years in Indonesian prison for drug-smuggling

A former Gloucestershire police community support officer who admitted drug-smuggling is facing 16 years in an Indonesian prison, if judges agree to prosecution demands.

Arts and Entertainment
Benedict Cumberbatch has refused to deny his involvement in the upcoming new Star Wars film
filmBenedict Cumberbatch reignites those Star Wars rumours
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Russell Brand has written a book of political analysis called Revolution
peopleFilm star says he is 'not interested in making money anymore'
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newsMcKamey Manor says 'there is no escape until the tour is completed'
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Britain First criticised for using actress's memory to draw attention to their 'hate-filled home page'

Arts and Entertainment
JK Rowling is releasing a new Harry Potter story about Dolores Umbridge
booksChristmas comes early for wizard fans
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Emergency call 'started off dumb, but got pretty serious'

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Arts and Entertainment
On The Apprentice, “serious” left the room many moons ago and yet still we watch
tv

Greatest mystery about the hit BBC1 show is how it continues to be made at all, writes Grace Dent

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Hunted: A stag lies dead on Jura, where David Cameron holidays and has himself stalked deer
voicesThe Scotland I know is becoming a playground for the rich
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Prices correct as of 17 October 2014
Wilko Johnson, now the bad news: musician splits with manager after police investigate assault claims

Wilko Johnson, now the bad news

Former Dr Feelgood splits with manager after police investigate assault claims
Mark Udall: The Democrat Senator with a fight on his hands ahead of the US midterm elections

Mark Udall: The Democrat Senator with a fight on his hands

The Senator for Colorado is for gay rights, for abortion rights – and in the Republicans’ sights as they threaten to take control of the Senate next month
New discoveries show more contact between far-flung prehistoric humans than had been thought

New discoveries show more contact between far-flung prehistoric humans than had been thought

Evidence found of contact between Easter Islanders and South America
Cerys Matthews reveals how her uncle taped 150 interviews for a biography of Dylan Thomas

Cerys Matthews on Dylan Thomas

The singer reveals how her uncle taped 150 interviews for a biography of the famous Welsh poet
DIY is not fun and we've finally realised this as a nation

Homebase closures: 'DIY is not fun'

Homebase has announced the closure of one in four of its stores. Nick Harding, who never did know his awl from his elbow, is glad to see the back of DIY
The Battle of the Five Armies: Air New Zealand releases new Hobbit-inspired in-flight video

Air New Zealand's wizard in-flight video

The airline has released a new Hobbit-inspired clip dubbed "The most epic safety video ever made"
Pumpkin spice is the flavour of the month - but can you stomach the sweetness?

Pumpkin spice is the flavour of the month

The combination of cinnamon, clove, nutmeg (and no actual pumpkin), now flavours everything from lattes to cream cheese in the US
11 best sonic skincare brushes

11 best sonic skincare brushes

Forget the flannel - take skincare to the next level by using your favourite cleanser with a sonic facial brush
Paul Scholes column: I'm not worried about Manchester United's defence - Chelsea test can be the making of Phil Jones and Marcos Rojo

Paul Scholes column

I'm not worried about Manchester United's defence - Chelsea test can be the making of Jones and Rojo
Frank Warren: Boxing has its problems but in all my time I've never seen a crooked fight

Frank Warren: Boxing has its problems but in all my time I've never seen a crooked fight

While other sports are stalked by corruption, we are an easy target for the critics
Jamie Roberts exclusive interview: 'I'm a man of my word – I'll stay in Paris'

Jamie Roberts: 'I'm a man of my word – I'll stay in Paris'

Wales centre says he’s not coming home but is looking to establish himself at Racing Métro
How could three tourists have been battered within an inch of their lives by a burglar in a plush London hotel?

A crime that reveals London's dark heart

How could three tourists have been battered within an inch of their lives by a burglar in a plush London hotel?
Meet 'Porridge' and 'Vampire': Chinese state TV is offering advice for citizens picking a Western moniker

Lost in translation: Western monikers

Chinese state TV is offering advice for citizens picking a Western moniker. Simon Usborne, who met a 'Porridge' and a 'Vampire' while in China, can see the problem
Handy hacks that make life easier: New book reveals how to rid your inbox of spam, protect your passwords and amplify your iPhone

Handy hacks that make life easier

New book reveals how to rid your email inbox of spam, protect your passwords and amplify your iPhone with a loo-roll
KidZania lets children try their hands at being a firefighter, doctor or factory worker for the day

KidZania: It's a small world

The new 'educational entertainment experience' in London's Shepherd's Bush will allow children to try out the jobs that are usually undertaken by adults, including firefighter, doctor or factory worker