Partygoers smoke marijuana during a Prohibition-era themed New Year's Eve party celebrating the start of retail pot sales in Denver

A pot of gold? Colorado's pilot scheme to legalise recreational marijuana could raise millions in tax dollars...

... and mark the beginning of a sea-change in attitudes around the globe

A man takes part in a collective cannabis smoking event in Denver, Colorado. Colorado will become the first state to allow the sale of marijuana for recreational use in shops from 1 January 2014

Green Wednesday: Colorado prepares for over the counter sale of recreational marijuana

Colorado will become the first state in the US to allow the sale of marijuana for recreational use in shops from New Year's Day

Police warning over 'Speckled Rolex' ecstasy pills after one man dies

The ecstasy-like yellow pills have been linked to the death of one and hospitalisation of four others in Northern Ireland

Film review: How to Make Money Selling Drugs makes some compelling arguments for legalisation

Documentaries about America’s “war on drugs” tend to be grim and earnest affairs.

Withdrawn arthritis drug Vioxx. It is hoped that genetic discoveries might lead to discover new medicines for this and other complex diseases

'Faulty' DNA discovery could point to cure for arthritis

Scientists have identified DNA associated with an increased risk of rheumatoid arthritis, holding out hope of a new treatment or even a cure.

Rebollo in 1996, when he attended a Mexican/US anti-drugs summit in Mexico City

General Jesus Gutierrez Rebollo: Mexican general who became a drugs czar but who was convicted of aiding a powerful narcotics cartel

Jesus Gutierrez Rebollo was a Mexican general who became a drug czar whose career ended in disgrace thanks to his arrest and conviction for aiding a powerful drug cartel. The general, one of the highest-level officials to have been convicted of drug-trafficking in Mexico, was hailed as a seasoned general of “impeccable integrity”.

Two inmates have been arrested on suspicion of murder after a prisoner was found dead at HMP Lindholme

Two inmates arrested after death of prisoner in Lindholme prison

A snap inspection in the summer was highly critical of the jail's wing for low-risk prisoners

Nigella Lawson, arrives at Isleworth Crown Court

Nigella Lawson evidence: Scotland Yard review shows this is a test of police’s attitude to celebrity drug use

Scotland Yard had initially said it would not take action but would review the decision if new evidence came to light

Nigella Lawson, arrives at Isleworth Crown Court in London

Nigella Lawson case: How come celebs aren't stopped and searched?

Yesterday morning we were told that Nigella Lawson is not to be investigated for cocaine use. During the trial of her two former aides she had admitted taking the drug, but the police have said she will not be investigated "at this stage". Well there's a thing.

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

When Newsnight became Brass Eye: Jeremy Paxman claims internet used to facilitate masturbation ‘or worse’

Jeremy Paxman announced what he thought the internet was really for during a segment on Wednesday night’s show

A mosquito waiting to be studied - scientists have identified the changes to the genes of the malaria parasite that make it resistant to one of the last effective drugs

Scientists identify resistance gene in malaria parasite

Discovery of genes that confer resistance to the drug artemisinin is major step forward for treatment of the disease

Melissa Reid, right, and Michaella McCollum arrive for their court hearing in Lima

Six years in a Peruvian jail for British women found with £1.5m of cocaine

Guilty pair Melissa Reid and Michaella McCollum could apply to serve their sentences here

GlaxoSmithKline

GlaxoSmithKline to stop paying doctors to promote its drugs

British pharmaceutical giant GlaxoSmithKline (GSK) has announced that it will stop paying doctors to promote its products, in a first for a major drugs company.

Matthew Perry sparks furious drug debate with Peter Hitchens on Newsnight

The pair formed part of a discussion on specialist drugs courts, in which former addicts will sit as lay magistrates

British national Andrea Waldeck reads a bible as she sits in a courtroom in Surabaya, Indonesia

Former police community support officer Andrea Waldeck faces 16 years in Indonesian prison for drug-smuggling

A former Gloucestershire police community support officer who admitted drug-smuggling is facing 16 years in an Indonesian prison, if judges agree to prosecution demands.

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Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

Cameron, Miliband and Clegg join forces for Homeless Veterans campaign

It's in all our interests to look after servicemen and women who fall on hard times, say party leaders
Millionaire Sol Campbell wades into wealthy backlash against Labour's mansion tax

Sol Campbell cries foul at Labour's mansion tax

The former England defender joins Myleene Klass, Griff Rhys Jones and Melvyn Bragg in criticising proposals
Nicolas Sarkozy returns: The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?

Sarkozy returns

The ex-President is preparing to fight for the leadership of France's main opposition party – but will he win big enough?
Is the criticism of Ed Miliband a coded form of anti-Semitism?

Is the criticism of Miliband anti-Semitic?

Attacks on the Labour leader have coalesced around a sense that he is different, weird, a man apart. But is the criticism more sinister?
Ouija boards are the must-have gift this Christmas, fuelled by a schlock horror film

Ouija boards are the must-have festive gift

Simon Usborne explores the appeal - and mysteries - of a century-old parlour game
There's a Good Girl exhibition: How female creatives are changing the way women are portrayed in advertising

In pictures: There's a Good Girl exhibition

The new exhibition reveals how female creatives are changing the way women are portrayed in advertising
UK firm Biscuiteers is giving cookies a makeover - from advent calendars to doll's houses

UK firm Biscuiteers is giving cookies a makeover

It worked with cupcakes, doughnuts and macarons so no wonder someone decided to revamp the humble biscuit
Can SkySaga capture the Minecraft magic?

Can SkySaga capture the Minecraft magic?

It's no surprise that the building game born in Sweden in 2009 and now played by millions, has imitators keen to construct their own mega money-spinner
The King's School is way ahead of the pack when it comes to using the latest classroom technology

Staying connected: The King's School

The school in Cambridgeshire is ahead of the pack when it comes to using the latest classroom technology. Richard Garner discovers how teachers and pupils stay connected
Christmas 2014: 23 best women's perfumes

Festively fragrant: the best women's perfumes

Give a loved one a luxe fragrance this year or treat yourself to a sensual pick-me-up
Arsenal vs Borussia Dortmund: Alex Oxlade-Chamberlain celebrates century with trademark display of speed and intuition

Arsenal vs Borussia Dortmund

The Ox celebrates century with trademark display of speed and intuition
Billy Joe Saunders vs Chris Eubank Jnr: When two worlds collide

When two worlds collide

Traveller Billy Joe Saunders did not have a pampered public-school upbringing - unlike Saturday’s opponent Chris Eubank Jnr
Homeless Veterans Christmas Appeal: Drifting and forgotten - turning lives around for ex-soldiers

Homeless Veterans Christmas Appeal: Turning lives around for ex-soldiers

Our partner charities help veterans on the brink – and get them back on their feet
Putin’s far-right ambition: Think-tank reveals how Russian President is wooing – and funding – populist parties across Europe to gain influence in the EU

Putin’s far-right ambition

Think-tank reveals how Russian President is wooing – and funding – populist parties across Europe to gain influence in the EU
Tove Jansson's Moominland: What was the inspiration for Finland's most famous family?

Escape to Moominland

What was the inspiration for Finland's most famous family?